Location & dates EMBL Heidelberg, Germany 23 - 26 May 2017
Deadlines Registration closed Abstract submission closed

EMBL Courses and Conferences during the Coronavirus pandemic

With the onsite programme paused, many of our events are now being offered in virtual formats.

Registration is open as usual for many events, with back-up plans in place to move further courses and conferences online as necessary. Registration fees for any events affected by the COVID-19 disruption are fully refundable.

More information for participants of events at EMBL Heidelberg can be found here.

Conference Programme

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Day 1 - Tuesday 23 May 2017
13.30-15.20 Registration and light refreshments


Opening remarks by Dónal O'Carroll
15.30-16.20 Keynote Lecture 1
Chair: Dónal O'Carroll
Lgr5 Stem Cell-based organoids in human disease
Hans Clevers, Hubrecht Institute, The Netherlands
16.20-18.35 Session 1 - Tissue stem cell specification/regulation and self-renewal
Chair: Dónal O'Carroll

Differentiation and dedifferentiation in mammalian epidermis
Fiona Watt, King's College London, UK


Ascl1 stabilisation facilitates cell cycle re-entry in the developing and adult brain
Noelia Urbán, The Francis Crick Institute, UK


Coffee Break


EMBO Young Investigator Lecture:
Modelling tissue repair in vivo and in vitro
Kim Jensen, University of Copenhagen, Denmark


Functional profiling of isogenic human stem cells
Ceren Gunes, TU Dresden, Germany


Vitamin A, dormancy and the stem-progenitor continuum
Andreas Trumpp, German Cancer Research Center, Germany

18.35-19.30 Speed networking & welcome drinks

Dinner in the EMBL Canteen

21.00-23.00 Welcome reception at the ATC Roof Top Lounge
Day 2 - Wednesday 24 May 2017
09.00-12.05 Session 1 continued - Tissue stem cell specification/regulation and self-renewal
Chair: Olivier Pourquie


Epigenetic mechanisms in early mammalian development: searching for global chromatin trends
Maria-Elena Torres Padilla, Institute of Epigenetics and Stem Cells, Helmholtz Zentrum München, Germany


Regulation of neural stem cell fate during development and adulthood
Yukiko Gotoh, The University of Tokyo, Japan


Zac1 is essential to maintain Muller glia in a quiescent stem cell state in the retina
Yacine Touahri, Sunnybrook Research Institute, University of Toronto, Canada


Dynamics of mammary stem cells during branching morphogenesis
Ben Simons, Cavendish Laboratory, TCM, University of Cambridge, United Kingdom

10.30-11.00 Coffee Break
11.00-11.25 Developmental patterning of human pluripotent stem cells: from beating cardiomycoytes to heart disease models
Christine L. Mummery, Leiden University Medical Center, The Netherlands
11.25-11.50 Epithelial stem cells during homeostasis and repair
Cedric Blanpain, University of Brussels, Belgium
11.50-12.05 Mechanisms of intestinal stem cell specification during mouse development
Natalia Soshnikova, Institute of Molecular Biology (IMB Mainz), Germany
12.05-13.30 Lunch and meet the speakers
13.30-15.30 Poster Session 1: numbers 47 to 97
13.30-14.30 EMBO Press discussion session: ‘Whereto Science Publishing’ at the ATC Courtyard Room
15.30-18.10 Session 2 - Stem cell niche, signalling
Chair: Fiona Watt
15.30-15.55 Mitochondrial changes in hematopoietc cells under stress
Toshio Suda, Cancer Science Institute, National University of Singapore, Singapore

Competition for FGFs yields robust homeostasis in the density of mouse spermatogenic stem cells
Shosei Yoshida, National Institute for Basic Biology, Japan


Understanding Notch signalling in Hematopoietic Stem Cell development
Anna Bigas, Hospital del Mar Medical Research Institute (IMIM), Spain


Coffee Break


Intestinal Parasites Reprogram the Intestinal Stem Cell Niche
Ysbrand Nusse, University of California at San Francisco, USA


The sexual identity of adult intestinal stem cells
Irene Miguel-Aliaga, Imperial College London, UK


Integration of systemic and local cues is required for neural stem cell niche morphogenesis in Drosophila
Pauline Spéder, Institut Pasteur, France


Session 3: EuroStemCell; Public engagement with stem cell research
Chair: Clare Blackburn


Introduction to EuroStemCell
Clare Blackburn, Jan Barfoot and Amande Waite


Demonstration of resources, games and activities that are suitable for open days, school visits, science festivals and other outreach activities by EuroStemCell, PluriMes, REVIVE and ThymiStem


Dinner in the EMBL Canteen

21.00-23.00 Wine and beer session at the ATC Roof Top Lounge
Day 3 - Thursday 25 May 2017
9.00-10.00 Session 4: Stem cell plasticity and regeneration
Chair: Shahragim Tajbakhsh
9.00-9.15 Generation of Human Artificial 3D Skeletal Muscle Tissue from Healthy and Dystrophic Pluripotent Stem Cells
Francesco Saverio Tedesco, University College London, UK
9.15-9.30 Cell-autonomous maintenance of muscle stem cells by Notch-induced collagen V activation of the Calcitonin Receptor
Meryem Baghdadi, Institut Pasteur, France
9.30-9.45 Senescence promotes In Vivo Reprogramming in Skeletal Muscle
Han Li, Institut Pasteur, France
9.45-10.00 Tissue damage and senescence promote in vivo reprogramming through the secretion of IL6
Lluc Mosteiro, Spanish National Cancer Research Centre (CNIO), Spain
10.00-13.15 Session 5: Stem cell regeneration, ageing and metabolism
Chair: Shahragim Tajbakhsh
10.00-10.50 Keynote Lecture 2
Epigenetic regulation of aging neural stem cells
Anne Brunet, Stanford University, USA

Nutrient conditioning of hematopoietic stem cell lineage specification
Naomi Taylor, IGMM, France


Coffee Break


Making skeletal muscle in vitro and in vivo
Olivier Pourquie, Harvard Medical School, Brigham and Women’s Hospital, Harvard Stem Cell Institute, USA


Retinal cell therapy using iPS cells
Masayo Takahashi, RIKEN, Japan


Metabolic regulation of stem cell frequency and tumor suppression in vivo
Sean Morrison, The University of Texas Southwestern Medical Center, USA


Restricted regeneration of  hematopoietic stem cells in vivo following inflammatory stress leads to hematopoietic tissue failure during ageing
Ruzhica Bogeska, German Cancer Research Center (DKFZ), Germany
13.15-15.00 Lunch and meet the speakers/ journal editors
15.00-17.20 Session 6: Single cell analysis of stem cell dynamics
Chair: Anne Brunet
15.00-15.25 Derivation of Pluripotent Stem Cells with in vivo Embryonic and Extraembryonic Potency
Hongkui Deng, Peking University, China

An interconnected network of pluripotency and lineage regulators controls exit from pluripotency
Johanna Goldmann, MIT/Whitehead, USA


Elucidating a Biological Program for Resetting Pluripotent Identity
Meng Li, University of Cambridge, UK


The hierarchical organisation of the hematopoietic system
Claus Nerlov, The University of Oxford, UK


Coffee Break


Unraveling Cortical Development Using Population and Single-cell RNA-Seq Data
Zahra Karimaddini, ETH Zurich, Switzerland


Pervasive discordance between mRNA and protein expression during embryonic stem cell differentiation
Stefan Semrau, Leiden University, The Netherlands


Session 7: Ethics and regulation in introduction of new cellular therapies
Chair: Anne Brunet


Deciphering the legal and ethical issues in stem cell regenerative medicine
Emmanuelle Rial-Sebbag, UMR1027, INSERM and Université Toulouse III—Paul Sabatier, France


Poster Session 2: numbers 98 to 148

19.45-21.00 Dinner in the EMBL Canteen
21.00-23.00 Wine and beer session at the ATC Roof Top Lounge
Day 4 - Friday 26 May 2017

Session 8: Stem cell based disease modelling and drug discovery
Chair: Thomas Graf

9.00-9.25 Dissecting epithelial plasticity with human mammary organoids 
Christina Scheel, Helmholtz Zentrum München, Germany
09.25-12.50 Session 9: Principles of development for stem cell engineering
Chair: Thomas Graf

Single cell contribution to pancreas organogenesis and reconstituted community behaviour in pancreas organoids
Anne Grapin-Botton, University of Copenhagen, Denmark


Thymus generation, and regeneration
Clare Blackburn, The University of Edinburgh, UK


Modelling human development with pluripotent stem cells
Gordon Keller, University Health Network, Canada

10.40-11.10 Coffee Break
11.10-11.35 From Human Stem Cell to Kidney Organoid to Disease Modelling
Joseph Bonventre, Brigham and Women's Hospital, Harvard Medical School, USA
11.35-12.00 Interactions between progenitor populations for the anteroposterior axis in mouse
Val Wilson, The University of Edinburgh, UK

Engineering organoid development in 3D synthetic microenvironments
Matthias Lutolf, Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland


Clonal and polyclonal origin of neuromesodermal progenitors in mammals
Alfonso Martinez Arias, University of Cambridge, UK


Lunch and meet the speakers


Poster Session 3: numbers 149 to 198


Session 10: Re-evaluating strategies for transplantation
Chair: Claus Nerlov


Regeneration of the damaged liver: bile ducts take over when hepatocyte regeneration fails
Stuart Forbes, The University of Edinburgh, UK


Keynote Lecture 3
Combined Ex vivo cell and gene therapy of epidermolysis bullosa by transgenic epidermal stem cells

Michele De Luca, University of Modena and Reggio Emilia, Italy


Closing remarks and Poster prize presentation by Claus Nerlov

18.00-19.00 Drinks Reception
19.00-24.00 Conference dinner and party