Location & dates EMBL Heidelberg, Germany 7 - 9 Jun 2018
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Day 1 - Thursday 7 June 2018
10:00 - 12:00 Arrival and Registration
with light refreshments
12:00 - 12:15 Opening Remarks
12:15 - 13:15

Keynote Lecture: Unraveling the biology of normal and malignant hematopoietic stem and progenitor cells at the single cell level
Sten Eirik Jacobsen - Karolinska Institutet, Sweden
Presenter: Christophe Lancrin

13:15 - 17:15 Session 1: Hematopoietic Stem Cells in the Embryo
Chairs: Thierry Jaffredo and Catherine Robin
13:15 - 13:45 Single cell transcriptomics reveal the dynamic of hematopoietic stem cell emergence and maturation in the aorta of the mouse embryo
Catherine Robin - Hubrecht Institute, The Netherlands
13:45 - 14:00

An ubiquitin proteasome pathway controls drosophila hematopoiesis
Michèle Crozatier - Centre de Biologie du Developpement, France

14:00 - 14:30

Analysis of hematopoietic cell formation in the major arteries of the mouse embryo
Nancy Speck - University of Pennsylvania, USA

14:30 - 15:00

Coffee Break and Meet the Speakers with:
Sten Eirik Jacobsen - Karolinska Institutet, Sweden
Catherine RobinHubrecht Institute, The Netherlands
Nancy SpeckUniversity of Pennsylvania, USA
Anna Bigas - Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Spain
Trista NorthBoston Childrens Hospital and Harvard Medical School, USA

15:00 - 15:15

A conserved endothelial enhancer in the gata2a locus reveals non redundant roles for Gata2a and Gata2b in embryonic and adult haematopoietic stem cells
Rui Monteiro - University of Birmingham, UK

15:15 - 15:45

Notch ligands shape the nascent hematopoietic stem cell niche in the embryonic aorta
Anna Bigas - Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Spain

15:45 - 16:00

Somite derived stromal cells, a key component of the HSC expansion/differentiation niche in zebrafish : first insights in the molecular mechanisms of their emergence from the somite
Emi Murayama - Institut Pasteur, France

16:00 - 16:30

From blood vessels to hematopoietic stem cells
Christophe Lancrin - EMBL Rome, Italy

16:30 - 17:00

Extrinsic regulation of hematopoiesis
Trista North - Boston Childrens Hospital and Harvard Medical School, USA

17:00 - 17:15 Flash Talk Session I
Julien Bertrand (abstract no. 38) - University of Geneva, Switzerland
Vashe Chandrakanthan (abstract no. 43) - University of New South Wales, Australia
Thomas Clapes (abstract no. 44) - Max Planck Institute of Immunobiology and Epigenetics, Germany
Marion Mesnieres (abstract no. 79) - KU Leuven, Belgium
Anne Schmidt (abstract no. 92) - Institut Pasteur, France
17:15 - 18:45 Poster Session I (odd numbers)
with beer and snacks
18:45 - 20:15

Dinner in EMBL Canteen

20:15 - 21:30 Speed Networking Session in EMBL Canteen
20:15 - 22:00 After Dinner Drinks with Live Music by Blue Note Jazz Duo in ATC Rooftop Lounge
Day 2 - Friday 8 June 2018
09:00 - 15:15 Session 2: Hematopoietic Stem Cells in the Adult Animal
Chairs: Roi Gazit and Christophe Lancrin
09:00 - 09:30 Metabolism meets the epigenome in AML stem cells
Andreas Trumpp - German Cancer Research Center (DKFZ) and HI‑STEM, Germany
09:30 - 09:45 Restriction of myelo lymphoid lineage potential occurs within the human haematopoietic stem cell pool
Emily Calderbank - University of Cambridge, UK
09:45 - 10:15 Cross talk between embryonic and adult hematopoiesis
Claudia Waskow - Leibniz Institute on Aging, Germany
10:15 - 10:30 Apelin positive endothelial cells control hematopoiesis and bone marrow transplantation
Qi Chen - Max Planck Institute for Molecular Biomedicine, Germany
10:30 - 11:00 Coffee Break and Meet the Speakers with:
Andreas Trumpp - German Cancer Research Center (DKFZ) and HI‑STEM, Germany
Claudia Waskow - Leibniz Institute on Aging, Germany
Shannon McKinney-Freeman - St. Jude Children's Research Hospital, USA
David Kent - University of Cambridge, UK
11:00 - 11:30 Exploring hematopoietic stem cell emergence during ontogeny
Shannon McKinney-Freeman - St. Jude Children's Research Hospital, USA
11:30 - 11:45 Investigating the role of Bone Marrow Stroma in the response of Haematopoietic Stem Cells to Plasmodium berghei infection
Myriam Haltalli - Imperial College London, UK
11:45 - 12:15 Tracking human hematopoietic stem cell clonal dynamics using somatic mutations
David Kent - University of Cambridge, UK
12:15 - 12:30

Flash Talk Session II
Nina Cabezas-Wallscheid (abstract no. 41) - Max Planck Institute of Immunobiology and Epigenetics, Germany
Kerstin Cornils (abstract no. 46) - University Medical Center Hamburg-Eppendorf, Germany
Marta Derecka (abstract no. 50) - Max Planck Institute of Immunobiology and Epigenetics, Germany
Tatyana Grinenko (abstract no. 58) - TU Dresden, Germany
Mina Morcos (abstract no. 56) - TU Dresden, Germany
Tamar Tak (abstract no. 97) - Institut Curie, France

12:30 - 13:30

Lunch and Meet the Editors in ATC Foyer with: 
Daniel Klimmeck - The EMBO Journal, Germany
Andrea Leibfried - Life Science Alliance, Germany
Achim Breiling - EMBO Reports, Germany
Celine Carret - EMBO Molecular Medicine, Germany

13:30 - 14:00

Deconstructing stem cell niche contributions to bone marrow failure and leukemogenesis
Marc Raaijmakers - Erasmus MC, The Netherlands

14:00 - 14:15 Decoding the regulatory circuit by epigenetic regulator MOF in haematopoiesis
Cecilia Rodrigues - Max Planck Institute, Germany
14:15 - 14:45 Metabolic regulation of blood and bone forming stem cells: The role of ROS, mitochondria transfer, nitric oxide and melatonin
Tvsee Lapidot - Weizmann Institute of Science, Israel
14:45 - 15:15 Functional heterogeneity and aging of blood vessels in the skeletal system
Ralf Adams - Max Planck Institute for Molecular Biomedicine, Germany
15:15 - 15:45 Coffee Break and Meet the Speakers with:
Marc Raaijmakers - Erasmus MC, The Netherlands
Tvsee Lapidot - Weizmann Institute of Science, Israel
Ralf Adams - Max Planck Institute for Molecular Biomedicine, Germany
Emmanuelle Passegué - Columbia University Medical Center, USA
Michael Milsom - HI-STEM, Germany
Amy Wagers Harvard University, USA
15:45 - 18:15 Session 3: Hematopoietic Stem Cells Aging
Chairs: Marc Raaijmakers and Leïla Perié    
15:45 - 16:15

Inflammaging – a crosstalk between two aging systems: Stroma and blood
Emmanuelle Passegué - Columbia University Medical Center, USA

16:15 - 16:30 Oncogene induced senescence in hematopoietic progenitors leads to myeloid restricted hematopoiesis, chronic inflammation and aggressive histiocytosis
Raffaella Di Micco - San Raffaele Institute for Gene Therapy (SR TIGET), Italy
16:30 - 17:00 Stress hematopoiesis and ageing
Michael Milsom - HI-STEM, Germany
17:00 - 17:15 Normal and malignant splicing in hematopoietic stem cells
Roi Gazit - Ben-Gurion University of the Negev, Israel
17:15 - 17:45 Intrinsic and extrinsic signals regulating stem cell aging
Amy Wagers - Harvard University, USA
17:45 - 18:00 Neogenin 1 defines the myeloid biased fraction of long  term Hoxb5+ hematopoietic stem cells (HSC) that expands during mobilization and aging
Krzysztof Szade - Stanford University, USA
18:00 - 18:15 Flash Talk Session III
Miguel Ganuza (abstract no. 55) - St. Jude Children's Research Hospital, USA
Emanuele Lettera (abstract no. 76) - San Raffaele Research Institute, Italy
Carolina Petrillo (abstract no. 84) - Ospedale San Raffaele, Italy
Rama Khokha on behalf of Sanjay Saw (abstract no. 91) - University Health Network, Canada
18:15 - 19:45 Poster Session II (even numbers)
with beer and snacks
19:45 - 21:00

Conference Dinner in EMBL Canteen

21:00 - 00:00 Conference Party with DJ Rotard and Photobooth in EMBL Canteen
Day 3 - Saturday 9 June 2018
09:00 - 14:00 Session 4: New technologies for Hematopoietic Stem Cells Research
Chairs: Nina Cabezas-Wallscheid and Julien Bertrand
09:00 - 09:30 Clonal analysis of native hematopoiesis
Fernando Camargo - Boston Children's Hospital, USA
09:30 - 09:45 A human ips model implicates embryonic b myeloid fate restriction as a developmental susceptibility to ETV6 RUNX1
Charlotta Böiers - Lund University, Sweden
09:45 - 10:00 Insights into the biological characteristics of hemogenic endothelium
Valerie Kouskoff - University of Manchester, UK
10:00 - 10:15 Uncovering the origin of Down syndrome associated leukemia
Sara Martina Maffioletti - San Raffaele Telethon Institute for Gene Therapy, Italy
10:15 - 10:45

Coffee Break and Meet the Speakers with:
Fernando Camargo - Boston Children's Hospital, USA
Hans-Reimer Rodewald - German Cancer Research Center (DKFZ), Germany
Leïla Perié - Institut Curie, France
Paul Frenette - Albert Einstein College of Medicine, USA

10:45 - 11:15 Hematopoiesis under steady state and under challenge dissected by fate mapping and Polylox barcoding
Hans-Reimer Rodewald - German Cancer Research Center (DKFZ), Germany

11:15 - 11:30

Somatic mutations reveal lineage relationships and age related mutagenesis in human hematopoiesis
Ruben van Boxtel - Princess Máxima Center, The Netherlands
11:30 - 12:00 Retracing the in vivo haematopoietic tree using cellular barcoding methods
Leïla Perié - Institut Curie, France
12:00 - 13:30 Lunch in EMBL Canteen
13:30 - 13:45 Multi layered single cell transcriptional profiling of all bone and bone marrow populations provides a systems view of the mesenchymal and hematopoietic stem cell niche
Jude Al-Sabah - HI-STEM and German Cancer Research Center (DKFZ), Germany
13:45 - 14:00 GFI1B molecular function in megakaryocytes from induced pluripotent stem cells
Marten Hansen - Sanquin, The Netherlands
14:00 - 15:00 Keynote Lecture: Young and old HSC niches
Paul Frenette - Albert Einstein College of Medicine, USA
Presenter: Catherine Robin
15:00 - 15:15 Closing Remarks and Poster Prize