Location & dates EMBL Heidelberg, Germany 25 - 28 Aug 2018
Deadlines Registration closed Abstract submission closed

Programme

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Day 1 - Saturday 25 August 2018
TimeSpeaker
15:00-18:00

Arrival and Registration
ATC Registration Desk

16:30 - 17:30

Pre-Conference Workshop
ATC Courtyard Seminar Room

18:00-18:15

Welcome and Opening Remarks
ATC Auditorium

18:15–20:00  Session 1
Chair: 
Eileen Furlong - EMBL Heidelberg, Germany
18:15-18:35

FIREnano and ChromEMT: Visualizing the structural basis
of gene activation and silencing in the nucleus
Clodagh O’Shea - Salk Institute for Biological Studies, United States of America

18:35-18:55 Gene Expression Within the Context of a Topologically Associating Domain
Douglas Higgs - University of Oxford, United Kingdom
18:55-19:10

RNA-mediated regulation of chromatin complexes
Roberto Bonasio - University of Pennsylvania, United States of America

19:10-19:25 Decoding the chromatin proteome of a single genomic locus by DNA sequencing
Fred van Leeuwen - Netherlands Cancer Institute, The Netherlands
19:25-19:45

Epigenetic Regulation of HIV Transcription
Melanie Ott - University of California San Francisco, United States of America

19:45-20:05 A sequence anomaly of the MLL promoter imposes a
transcription factor addiction in leukemia

Chris Vakoc - Cold Spring Harbor Laboratory, United States of America
20:05-21:30

Dinner
EMBL Canteen

21:30-23:00

Welcome Reception
ATC Foyer and Roof Top Lounge

Day 2 - Sunday 26 August 2018
TimeSpeaker
09:00-12:40

Session 2
Co-Chairs:
Peter Verrijzer - Erasmus MC, The Netherlands
Wendy Bickmore - The University of Edinburgh, United Kingdom

09:00-09:20

The Argonaut NRDE-3 and MET-2 redundantly target SET-25 to transposable elements and genes
Jan Padeken -  Friedrich Miescher Institute for Biomedical Research, Switzerland

09:20-09:40

Induced activation of Polycomb-repressed genes in mice
Haruhiko Koseki - Laboratory for Developmental Genetics | RIKEN, Japan

09:40-09:55 Independent and overlapping roles of PRC2.1 and PRC2.2 complexes in the localisation of H3K27me2 and H3K27me3 in ESCs
Adrian Bracken - Trinity College Dublin, Ireland  
09:55-10:10 Comprehensive theoretical analysis of the Polycomb – Trithorax system predicts that poised chromatin is robustly bistable and minimally bivalent
Leonie Ringrose - Humboldt University, Germany
10:10-10:25 Targeting the X chromosome for dosage compensation
Peter Becker - Ludwig-Maximilians-Universität München, Germany
10:25-10:45

Molecular basis of chromatin binding and modification by histone lysine methyltransferases
Jürg Müller - Max Planck Institute of Biochemistry, Germany

10:45-11:15 Coffee break
ATC Foyer
11:15-11:35

GPIF limits Polycomb Repressive Complex 2 activity in mammalian germ cells
Raphaël Margueron - Institut Curie, France

11:35-11:50 EMBO Young Investigator Lecture
Modelling the pathological long-range regulatory effects of structural variation with patient-specific hiPSC
Alvaro Rada-Iglesias - University of  Cologne, Germany
11:50-12:05 Telobox motifs recruit CLF/SWN-PRC2 for H3K27me3 deposition via TRB factors in Arabidopsis
Franziska Turck - Max Planck Institute for Plant Breeding Research, Germany
12:05-12:20

Recruitment of Polycomb Repressive Complex 2 by MTF2 in embryonic stem cells contributes to lineage specification
Gert Veenstra - Radboud University, The Netherlands              

12:20-12:40 The Epigenetic Status of some Histone Post-Translational Modifications
Danny Reinberg - Howard Hughes Medical Institute at NYU School of Medicine,
United States of America
12:40-14:30 Lunch
EMBL Canteen
14:30-17:00 Poster Session 1: Odd numbers
ATC Helices A & B
17:00-19:20

Session 3
Chair: Michael Levine - Princeton University, United States of America

17:00-17:20 Deciphering Transcriptional Regulation of Human Core Promoters
Eran Segal - Weizmann Institute of Science, Israel
17:20-17:40 Transcriptional cofactors display core promoter class-specificity
Alexander Stark - IMP, Vienna, Austria
17:40-17:55 The Evolution of Long-range Gene Regulation at the HoxD locus
Denis Duboule - University of Geneva and École Polytechnique Fédérale de Lausanne, Switzerland
17:55-18:10 Exploring the Molecular Basis of Cis-Regulatory Robustness uncovers a Playground for Adaptation of Gene Expression during Evolutionary Diversification of Vertebrate Limbs
Rolf Zeller - University of Basel, Switzerland
18:10-18:25 Functional insights into genome topology and enhancer function during embryonic development
Eileen Furlong - EMBL, Heidelberg, Germany
18:25-18:40 GRO-Seq data resource for identification of pri-miRNAs and keystone enhancers
Minna Kaikkonen - University of Eastern Finland
18:40-19:00

The Remote Control of Gene Expression
Wendy Bickmore - The University of Edinburgh, United Kingdom

19:00-19:15

Dynamics of X-chromosome organisation in the context of genome-wide changes during early mouse embryo development 
Samuel Collombet - Institut Curie, France

19:20-21:30 Dinner
EMBL Canteen
21:30-23:00 After Dinner Drinks
ATC Foyer and Rooftop Lounge
Day 3 - Monday 27 August 2018
TimeSpeaker
09:00-12:40

Session 4
Co-Chairs: 
Karen Adelman - Harvard Medical School, United States of America
Denis Duboule - University of Geneva and Ecole polytechnique fédérale de Lausanne, Switzerland

09:00-09:20

Variable silencing of the repeat genome – implications for non-genetic inheritance
Anne Ferguson-Smith, University of Cambridge, United Kingdom

09:20-09:40

A single ubiquitylation site in RNA Polymerase II regulates the transcriptional response to UV damage
Jesper Svejstrup - The Francis Crick Institute, United Kingdom

09:40-09:55

Long-range chromatin interactions on the inactive X and at Hox clusters are regulated by the non-canonical SMC protein Smchd1
Marnie Blewitt - Walter and Eliza Hall Institute for Medical Research, Australia

09:55-10:10

Parallel assessment of enhancer activity in distinct cell types of a complex mammalian tissue
Arnaud Krebs - EMBL Heidelberg, Germany

10:10-10:25

Beyond transcription amplification: MYC-driven oncogenic enhancer reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state
Alessio Zippo - University of Trento, Italy

10:25-10:45

Common Threads: Metabolism, Epigenetics and the Circadian Clock
Paolo Sassone-Corsi - University of California Irvine, United States of America

10:45-11:15

Coffee Break
ATC Foyer

11:15-11:35

To be presented onsite
Xavier Darzacq - University of California Berkeley, USA

11:35-11:50

Chromatin structure shapes the diffusion dynamics of transcription factors
Nacho Molina - CERBM – Institute of Genetics and Molecular and Cellular Biology (IGBMC), France

11:50-12:05

Mitotic chromosome association predicts genome-wide transcription factor occupancy and impact on local chromatin accessibility
David Suter - École Polytechnique Fédérale de Lausanne, Switzerland

12:05-12:20

Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome
Chunaram Choudhary - University of Copenhagen, Denmark

12:20-12:40

Visualization of Transcription Hubs in Living Drosophila Embryos
Michael Levine - Princeton University, United States of America

12:40-14:30

Lunch
ATC Foyer

14:30-17:00

Poster Session 2: Even numbers
ATC Helices A & B

17.00-19:20

Session 5
Chair: Marc Timmers - University of Freiburg, Germany

17:00-17:20

SWI/SNF (BAF) chromatin remodeling complexes are frequently mutated in cancer: Mechanisms and vulnerabilities
Charles Roberts - St. Jude Children's Research Hospital, United States of America

17:20-17:40

Phase-separation mechanisms in heterochromatin
Geeta Narlikar - University of California, San Francisco, United States of America

17:40-17:55

Transcription and chromatin control by ubiquitin specific protease 7 (USP7)
Peter Verrijzer - Erasmus MC, The Netherlands

17:55-18:10

Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma
Gerard Brien - Trinity College Dublin, Ireland

18:10-18:25

Click Chemistry Enables Preclinical Evaluation Of Targeted Epigenetic Therapies
Paola Grandi - Cellzome, Germany

18:25-18:40

Implementation of the histone acetyl transferase modules in the SAGA and NuA4 co-activators
Patrick Schultz - Institute of Genetics and Molecular and Cellular Biology (IGBMC), France

18:40-19:00 Deconstructing the Relationship between Chromatin and Transcription during Ultradian Metabolic Cycles
Jane Mellor - University of Oxford, United Kingdom
19:00-19:20 Principles of Epigenetics and Chromatin in Development and Human Disease
Ali Shilatifard - Northwestern University Feinberg School of Medicine, United States of America
19:20-21:30 Dinner
EMBL Canteen
21:30-23:00

After Dinner Drinks

ATC Foyer and ATC Rooftop Lounge

Day 4 - Tuesday 28 August 2018
TimeSpeaker
09:00-12:40

Session 6
Co-Chairs:
Tony Kouzarides - University of Cambridge, United Kingdom
Katherine Jones - Salk Institute for Biological Studies, United States of America

09:00-09:20

A molecular mechanism for RNA polymerase II activation
Patrick Cramer - Max Planck Institute for Biophysical Chemistry, Germany

09:20-09:40

The RNAPII CTD kinase, CDK12, cooperates with mTORC1 to regulate gene-specific translation of protein critical for mitotic genome stability
Katherine Jones - Salk Institute for Biological Studies, United States of America

09:40-09:55

Making sense of non-coding transcription at enhancers
Karen Adelman - Harvard Medical School, United States of America

09:55-10:10

Transcription termination and genome organisation
Jean-Christophe Andrau - CNRS, France

10:10-10:25

PHF3 binds RNA polymerase II via the SPOC domain and regulates transcription of neuronal genes
Dea Slade - University of Vienna, Austria

10:25-10:45

The TRiC/CCT chaperonin complex acts as a checkpoint in assembly of the basal transcription factor TFIID
Marc Timmers - University of Freiburg, Germany

10:45-11:15

Coffee Break
ATC Foyer

11:15-11:35

Epigenetic modulation of a preserved 3D chromatin landscape in two distinct states of pluripotency
Henk Stunnenberg - Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, The Netherlands

11:35-11:50

NF-Y controls fidelity of transcription initiation at gene promoters through maintenance of the nucleosome-depleted region
Andrew Oldfield - IGH, France

11:50-12:05

Recruitment of chromatin remodeler Isw1b depends both on histone H3K36 methylation and DNA-binding
Michaela Smolle - Biomedical Center, Ludwig-Maximilians-Universität München, Germany

12:05-12:20

Targeting nucleosomes by transcription factors in reprogramming
Abdenour Soufi - University of Edinburgh, United Kingdom

12:20-12:40

Transposable elements, their controllers and the speciation of human early embryogenesis
Didier Trono - École Polytechnique Fédérale de Lausanne, Switzerland

12:40-14:30

Lunch
ATC Foyer

14:30-17:00

Poster Session 3: Odd and even numbers
ATC Helices A & B

17:00-19:30

Session 7
Chair:  Henk Stunnenberg - Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, The Netherlands

17:00-17:20

Mechanisms of reprogramming to pluripotency
Kathrin Plath - University of California Los Angeles, United States of America

17:20-17:40

A GADD45a-ING1-C/EBP axis regulates energy homeostasis and organismal aging
Christof Niehrs -Institute of Molecular Biology (IMB), Germany

17:40-17:55

Repression of divergent noncoding transcription by a sequence-specific transcription factor
Folkert van Werven - The Francis Crick Institute, United Kingdom

17:55-18:10

Transcription factors activate genes through the phase separation capacity of their activation domains
Ann Boija - Whitehead Institute for Biomedical Research, United States of America

18:10-18:25

Co-translation drives the assembly of mammalian transcription regulatory multi-subunit complexes
Laszlo Tora - Institute of Genetics and Molecular and Cellular Biology (IGBMC), France

18:25-18:45

Probing the transcriptional consequences of Ras and Rho activation
Richard Treisman
- The Francis Crick Institute, United Kingdom

18:45-19:05 Modifications of RNA: their function and role in cancer
Tony Kouzarides - Gurdon Institute, University of Cambridge, United Kingdom
19:05-19:15 Closing Remarks
19:30-01:00

Dinner and Party
EMBL Canteen and ATC Foyer