Location & dates EMBL Heidelberg, Germany 5 - 10 May 2019
Deadlines Registration closed Abstract submission closed
Organiser_IBIS

Programme

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Day 1 - Sunday 5 May 2019
(Educational Day, Keynote Lecture and Welcome Reception)
TimeSpeakerLocation
Introductory Course: Iron Essentials for Clinicians and Scientists
Coordinated by Jodie Babitt, Hal Drakesmith and Ioav Cabantchik
08:00 - 09:00 Arrival and Registration for Educational Day
with light refreshments
ATC Registration Desk
09:00 - 09:05 Introductory Remarks 
Ioav Cabantchik, President IBIS - Hebrew University of Jerusalem, Israel
ATC Auditorium
09:05 - 12:30 Session 1: Basic Properties and Methodologies 
Chairs: Robert Fleming and Greg Anderson
ATC Auditorium
09:05 - 09:45 Bioiron: origin, chemical properties and evolution
Kostas Pantopoulos - McGill University, Canada
09:45 - 10:30 Iron transport proteins: gateways of cellular and systemic iron homeostasis 
Mitchell Knutson - University of Florida, USA
10:30 - 11:00 Coffee Break  ATC Auditorium Foyer
11:00 - 11:45 Mechanisms controlling cellular iron homeostasis in eukaryotes 
Rick Eisenstein - University of Wisconsin-Madison, USA
11:45 - 12:30 Systemic iron homeostasis 
Jodie Babitt - Massachusetts General Hospital, Harvard Medical School, USA
12:30 - 13:30 Lunch EMBL Canteen
13:30 - 15:30 Session 2: Genetic and Acquired Iron Disorders
Chairs: Clara Camaschella and Günter Weiss
ATC Auditorium
13:30 - 14:00 Genetic diseases causing iron deficiency and iron overload: two faces of the same coin 
Laura Silvestri - San Raffaele Scientific Institute, Italy
14:00 - 14:30 Erythropoiesis and iron metabolism: crosstalk, implications, and therapeutic options in iron loading anemias 
Yelena Ginzburg - Icahn School of Medicine at Mount Sinai, USA
14:30 - 15:30 Iron in cancer, infection, kidney and liver diseases: innocent bystander or therapeutic target? 
Igor Theurl - University Hospital of Innsbruck, Austria and Heinz Zoller - Medical University of Innsbruck, Austria
15:30 - 16:00 Coffee Break ATC Auditorium Foyer
16:00 - 17:30 Session 3: Global Issues
Chairs: Domenico Girelli and Dorine Swinkels
ATC Auditorium
16:00 - 16:45 The pathophysiology and diagnosis of iron deficiency and anaemia in populations and patients 
Sant-Rayn Pasricha - Walter and Eliza Hall Institute, Australia
16:45 - 17:30 Nutritional (dietary) and "functional" deficiencies in the first and third world 
Michael Zimmermann - ETH Zürich, Switzerland
17:30 - 18:00 Session 4: The Future of BioIron
Chair: Hal Drakesmith
ATC Auditorium
17:30 - 18:00 Open questions in basic and clinical iron research
Elizabeta Nemeth - University of California, Los Angeles, USA and Tomas Ganz - University of California, Los Angeles, USA
17:30 - 18:30 Arrival and Registration for Keynote Lecture and Welcome Reception ATC Registration Desk
18:30 - 19:30 Keynote Lecture: The microbiome
Peer Bork - EMBL Heidelberg, Germany
ATC Auditorium
19:30 - 21:30 Welcome Reception
with nibbles and refreshments
ATC Auditorium Foyer
Day 2 - Monday 6 May 2019
TimeSpeakerLocation
08:00 - 08:45 Arrival and Registration ATC Registration Desk
08:45 - 09:00 Welcome Remarks 
Ioav Cabantchik - Hebrew University of Jerusalem, Israel
Matthias Hentze - EMBL Heidelberg, Germany
Martina Muckenthaler - University of Heidelberg, Germany

ATC Auditorium

(streamed to ATC Courtyard Room A & B)
09:00 - 12:30 Plenary 1: Cell Biology of Iron Metabolism 
Chairs: Bruno Galy and Matthias Hentze

ATC Auditorium

(streamed to ATC Courtyard Room A & B)
09:00 - 09:30 Mechanisms of ferroptosis
Marcus Conrad - Helmholtz Zentrum München, Germany
09:30 - 09:45 Mechanisms, Pathways and Regulation of Mammalian Ferritin Secretion
Lior Spektor - The Technion, Israel
09:45 - 10:00 Novel mechanistic insights into the regulation of BMP-SMAD pathway and hepcidin expression by FKBP12
Alessandro Dulja -  San Raffaele Scientific Institute, Italy
10:00 - 10:15 A novel role for peroxisomal proteins in iron homeostasis
Nathan Subramaniam - Queensland University of Technology, Australia
10:15 - 10:30 A Systems Genetics Approach to Identify Genes and Pathways Involved in Liver Iron Overload and Pathology
Brie Fuqua - University of California, Los Angeles, United States of America
10:30 - 11:00 Coffee Break ATC Foyer
11:00 - 12:30 Plenary 1: Cell Biology of Iron Metabolism (continued)
Chairs: Mitchell Knutson and Marie-Paule Roth

ATC Auditorium

(streamed to ATC Courtyard Room A & B)
11:00 - 11:30 Role of the iron-sensing receptor Tfr2 in bone
Martina Rauner - Bone Lab Dresden, Germany
11:30 - 12:00 Regulation of Transferrin Receptor via S-acylation
Aurelio Teleman - German Cancer Research Center, Germany
12:00 - 12:15 Ncoa4-mediated ferritinophagy maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms
Joseph Mancias - Dana-Farber Cancer Institute, United States of America
12:15 - 12:30

PCBP1-mediated iron binding and delivery in the cytosol: mechanisms and impacts
Caroline Philpott -  National Institute of Diabetes and Digestive and Kidney Diseases, United States of America

12:30 - 14:00 Lunch ATC Auditorium Foyer
14:00 - 15:30 Concurrent Session 1: Iron Deficiency in Cancer Patients: A Clinical Perspective
Chairs: Max Gassmann and Andrea Steinbicker
ATC Auditorium
14:00 - 14:20 Iron deficiency in cancer patients: an emerging issue but difficult to define
Domenico Girelli - University of Verona, Italy
14:20 - 14:40 Management of anemia and iron deficiency in cancer patients: what guidelines say
Manuel Muñoz - University of Malaga, Spain
14:40 - 15:00 Perioperative anemia and iron deficiency in oncological surgery
Donat Spahn - University Hospital of Zurich, Switzerland
15:00 - 15:30 Round Table Discussion
14:00 - 15:30 Concurrent Session 2: Erythropoiesis and Iron 
Chairs: Robert Fleming and Antonella Nai
Large Operon
14:00 - 14:30 Gene therapy to cure hemoglobinopathies
Marina Cavazzana - Hôpital Necker - Enfants Malades, France

14:30 - 14:45

Combining Tfr2-haploinsufficiency with TMPRSS6-antisense oligonucleotides strongly ameliorates the hematological phenotype of thalassemic mice
Antonella Nai - San Raffaele Scientific Institute, Italy
14:45 - 15:00 The regulation of ferroportin and iron regulatory protein 2 on erythropoiesis
Deliang Zhang - NICHD, NIH, United States of America
15:00 - 15:15 The role of glutathione peroxidase 4 and vitamin E in reticulocyte maturation and iron homeostasis
Georg W. Bornkamm - Helmholtz Zentrum München, Germany
15:15 - 15:30 AMPK Regulates the Expression of the Fe-S cluster assembly enzyme (ISCU) and ALAS2, Modulating Cellular Iron Metabolism and Increasing Hemoglobin Synthesis
Ping La - Children's Hospital of Philadelphia, United States of America
14:00 - 15:30 Concurrent Session 3: Heme Physiology and Pathophysiology 
Chairs: Iqbal Hamza and Emanuela Tolosano
ATC Courtyard Room A & B
14:00 - 14:15 The safe coordinated trafficking of heme and iron after heme-hemopexin endocytosis requires copper for cell homeostasis
Ann Smith - University of Missouri-Kansa City, United States of America
14:15 - 14:30 Heme Cytotoxicity In The Brain: Microglia Polarization And Neuronal Damage
Illyane Lima - NOVA University Lisbon, Portugal
14:30 - 14:45 Iron deposition associated to vascular damage and hemolysis causes senescence and fibrosis
Mate Maus - Institute for Research in Biomedicine, Spain
14:45 - 15:00 Modulating heme biosynthesis alters Toxoplasma sensitivity to antimalarials
Clare Harding - University of Glasgow, United Kingdom
15:00 - 15:15 Metabolic adaptation in colorectal cancer: heme export is required for the modulation of the tricarboxylic acid cycle
Veronica Fiorito - University of Torino, Italy
15:15 - 15:30 Heme synthesis/Heme export axis as a novel regulator of cellular oxidative metabolism
Emanuela Tolosano - University of Torino, Italy
15:30 - 16:00 Coffee Break ATC Auditorium Foyer
16:00 - 17:30 Concurrent Session 4: Infection and Inflammation 
Chairs: Günter Weiss and Caroline Philpott
ATC Auditorium
16:00 - 16:15 Non-Transferrin-Bound Iron in Hematopoietic Stem Cell Transplanted Patients Serves as Iron Source for Aspergillus fumigatus Outgrowth
Verena Petzer - Medical University of Innsbruck, Austria
16:15 - 16:30 Reduction in erythrocyte life span as a key component of mycobacteria induced anemia
Maria Salomé Gomes - University of Porto, Portugal
16:30 - 16:45 The role of TNFa and IFNg in anemia of inflammation, immunity and stress erythropoiesis
Stefano Rivella - CHOP, United States of America
16:45 - 17:00 Hepcidin-mediated hypoferremic response to acute inflammation requires a threshold of Bmp6/Hjv/Smad signaling
Carine Fillebeen - McGill University, Canada
17:00 - 17:15 Hemolysis and intracellular heme confer protection against anti-CD40-triggered macrophage activation syndrome and vaso-occlusive inflammatory liver disease
Giada Ingoglia - University of Zurich, Switzerland
17:00 - 17:30 Anemia in infants at age 10-24 weeks predicts reduced long-term efficacy of diphtheria vaccine: a 2-year prospective observational study in rural Kenya
Nicole Stoffel - ETH Zurich, Switzerland
16:00 - 17:30 Concurrent Session 5: Liver Iron-Sensing and Control of the Hepcidin/Ferroportin Regulatory System
Chairs: Laura Silvestri and Jodie Babitt
Large Operon
16:00 - 16:30 New modes of hepcidin regulation
Hal Drakesmith - University of Oxford, United Kingdom
16:30 - 16:45 Endothelial Bmp2 knockout exacerbates hemochromatosis in Hfe knockout mice but not Bmp6 knockout mice
Xia Xiao - Massachusetts General Hospital, Harvard Medical School, United States of America
16:45 - 17:00 The hemochromatosis proteins are dispensable for acute BMP2-mediated hepcidin upregulation in mice
Alessia Pagani - OSR-San Raffaele Scientific Institute, Italy
17:00 - 17:15 MyD88 regulates the expression of SMAD4 and the iron regulatory hormone hepcidin
Macha Samba-Mondonga - Centre de recherche du CHUM, Université de Montréal, Canada
17:15 - 17:30 Spatial zonation of hepcidin in the liver is patterned by testosterone
Hélène Coppin - Inserm, France
16:00 - 17:30 Concurrent Session 6: Iron and Neurodegeneration 
Chairs: Raffaella Gozzelino and Ashley Bush
ATC Courtyard Room A & B
16:00 - 16:30 Title to be announced
David Devos - Centre Hospitalier Régional Universitaire de Lille, France
16:30 - 16:45 Evidence for Communication Between Systemic Iron Status and Cerebrospinal Fluid:  Clinical Implications for Therapeutic Strategy
James Connor - The Pennyslvania State University, United States of America
16:45 - 17:00 Mitochondrial ferritin attenuates ferroptosis and ER-stress induced apoptosis in an experimental model of ischemic stroke
Peina Wang - Hebei Normal University, China
17:00 - 17:15 How and why does iron storage fail with age?
Gawain McColl - The Florey Institute of Neuroscience and Mental Health, Australia
17:15 - 17:30 Changes In Gut Microbiota: An Early Event in Parkinson’s Disease
Raffaella Gozzelino - NOVA University of Lisbon, Portugal
16:00 - 17:30 Concurrent Session 7: Iron Deficiency Disorders and Their Treatment
Chairs: Diego Moretti and Heinz Zoller
Small Operon
16:00 - 16:15 The effect of genetic variation in TMPRSS6 (SNP rs855791) on iron metabolism and oral iron absorption: a stable iron isotope study in Taiwanese women
Sung-Nan Pei - Chia-Yi Chang Gung Memorial Hospital, Taiwan
16:15 - 16:30 Tmprss6-/- mice show plasma FGF23 elevation that is influenced by Fgf23 gene dosage
Xiuqi Li - Yale School of Medicine, United States of America
16:30 - 16:45 Generation and Development of KY1070, a fully human anti-BMP6 antibody for treatment of Anemia of Chronic Disease
Volker Germaschewski - Kymab, United Kingdom
16:45 - 17:00 Iron deficiency and a genetic risk score derived from GWAS are associated with Restless Legs Syndrome and its severity in 20,000 blood donors
David J. Roberts - University of Oxford, United Kingdom
17:00 - 17:15 Novel formulations to fortify rice with iron: evidence and public health potential
Diego Moretti - Swiss Distance University of Applied Sciences, Switzerland
17:15 - 17:30 Fecal microbiota as a biomarker to predict the tissue iron accumulation in intestine epithelial cells and liver
Liwei Xie - Guangdong Institute of Microbiology, China
17:30 - 18:00

Meet the Master 
Interview with Maria de Sousa
with refreshments

Video streamed.
18:00 - 19:30 Dinner  EMBL Canteen
19:30 - 20:30

Open Debate: Controversies in Bioiron
Topic: Intravenous Iron Supplementation in Chronic Cardiac Failure
Moderator: Tomas Ganz
In Favor: Iain Macdougall - King's College Hospital, UK
Against: Hossein Ardehali - Northwestern University, USA

ATC Courtyard A & B
19:30 - 22:00 Poster Session I (odd numbers)
with drinks and snacks
ATC Helix A & B
Day 3 - Tuesday 7 May 2019
TimeSpeakerLocation
07:45 - 08:45

Meet the Expert 1: Gene Therapy for Iron Disorders
Stefano Rivella - University of Pennsylvania, USA

Concurrent sessions. Students / trainees only - Space is limited, pre-registration essential.

ATC Helix Seminar Room A
07:45 - 08:45

Meet the Expert 2: Tracing the Intracellular Dynamics of Iron and Heme
Iqbal Hamza - University of Maryland, USA

Concurrent sessions. Students / trainees only - Space is limited, pre-registration essential.

ATC Helix Seminar Room B
09:00 - 12:30 Plenary 2: Disorders of Iron Metabolism
Chairs: Clara Camaschella and Antonello Pietrangelo
ATC Auditorium

(streamed to ATC Courtyard Room A & B)

09:00 - 09:30 The impact of dietary iron on gut microbiota and liver metabolism 
Manuela Raffatellu -  University of California, San Diego, USA 
09:30 - 10:00 Ferritinophagy
Francesca Carlomagno - University of Naples Federico II, Italy
10:00 - 10:15 The Natural History of Ferroportin Disease – First Results of the International, Multicenter non-HFE Registry
Benedikt Schaefer - Medical University of Innsbruck, Austria
10:15 - 10:30 New insights into the molecular mechanisms underlying the pro-atherosclerotic effect of non-transferrin-bound iron
Francesca Vinchi - New York Blood Center, United States of America
10:30 - 11:00 Coffee Break ATC Auditorium Foyer
11:00 - 12:30 Plenary 2: Disorders of Iron Metabolism (continued)
Chairs: Tomas Ganz and Stefano Rivella
ATC Auditorium

(streamed to ATC Courtyard Room A & B)

11:00 - 11:30 Treating Leukemia with oxidative ferrotherapy
Monica Guzman - Cornell University, USA
11:30 - 12:00 Iron, ferroptosis, aging and Alzheimer’s disease
Ashley Bush - The Florey Institute of Neuroscience and Mental Health, Australia
12:00 - 12:15 Differential effects of IRP1 deficiency versus HIF-2a IRE deletion on postnatal erythropoiesis in mice
Rick Eisenstein - University of Wisconsin-Madison, United States of America
12:15 - 12:30 Absence of iron-responsive element-binding protein 2 causes a novel neurodegenerative syndrome
Nunziata Maio - National Institutes of Health, United States of America
12:30 Packed Lunch  ATC Auditorium Foyer
From 12:30 Free Afternoon
19:00 - 20:30 Drinks Reception with Live Music
Ticketed event. Held off-site - more details to come.
Heidelberg Castle
Day 4 - Wednesday 8 May 2019
TimeSpeakerLocation
07:45 - 08:45

Meet the Expert 3: Translating Biologic Discoveries to Clinical Practice
Tomas Ganz - University of California, Los Angeles, USA
Elizabeta Nemeth - University of California, Los Angeles, USA

Concurrent sessions. Students / trainees only - Space is limited, pre-registration essential
ATC Helix Seminar Room A
07:45 - 08:45

Meet the Expert 4: Biophysical Approaches to Iron Speciation in Cells and Organ Development
Robert Hider - King's College London, UK
Paul Lindahl - Texas A&M University, USA

Concurrent sessions. Students / trainees only - Space is limited, pre-registration essential.
ATC Helix Seminar Room B
09:00 - 12:30

Plenary 3: Biology of Iron-Sulfur Proteins
Chairs: Roland Lill* and Ioav Cabantchik

(* COST Action 15133 "The Biogenesis of Iron-sulfur Proteins: from Cellular Biology to Molecular Aspects (FeSBioNet))

ATC Auditorium

(streamed to ATC Courtyard Room A & B)
09:00 - 09:30 Iron homeostasis regulates facultative heterochromatin assembly in adaptive genome control
Shiv Grewal - National Institutes of Health, USA
09:30 - 10:00 Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification
Elisabeth Leibold - University of Utah, USA
10:00 - 10:30 Friedreich ataxia: role of frataxin and pathophysiological consequences
Hélène Puccio* - Institute of Genetics and Molecular and Cellular Biology, France
10:30 - 11:00 Coffee Break ATC Auditorium Foyer
11:00 - 12:30

Plenary 3: Biology of Iron-Sulfur Proteins (continued)
Chairs: Tracey Rouault and Caroline Enns

(* COST Action 15133 "The Biogenesis of Iron-sulfur Proteins: from Cellular Biology to Molecular Aspects (FeSBioNet))

ATC Auditorium

(streamed to ATC Courtyard Room A & B)
11:00 - 11:30 Cytosolic and nuclear iron-sulfur protein assembly
Oliver Stehling* - Philipps University of Marburg, Germany
11:30 - 12:00 The lability of the NEET proteins' iron sulphur cluster: biomedical implication
Rachel Nechushtai* - Hebrew University of Jerusalem, Israel
12:00 - 12:15 Fe-S cluster biogenesis in DNA repair proteins: Structural studies of the CIA machinery
Susanne Kassube - Friedrich Miescher Institute for Biomedical Research, Switzerland
12:15 - 12:30 Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis
Nunziata Maio - National Institutes of Health, USA
12:30 - 14:15 Lunch  ATC Auditorium Foyer
14:15 - 15:15 Concurrent Session 8: Cardiovascular Disease 
Chairs: Hossein Ardehali and Samira Lakhal-Littleton
ATC Auditorium
14:15 - 14:30 Unexpected differences in cardiac iron metabolism and survival in Hepcidin-ko and FpnC326S mice
Sandro Altamura - University of Heidelberg, Germany
14:30 - 14:45 Role of mTOR-TTP Pathway in cardiac response to iron deficiency
Hossein Ardehali - Northwestern University, United States of America
14:45 - 15:00 Smooth muscle cell iron retention contributes to the pathology of Abdominal Aortic Aneurysm
Paul Loick - University of Oxford, United Kingdom
15:00 - 15:15 Interfering with endothelial heme metabolism to control the angiogenic process
Sara Petrillo - University of Turin, Italy
14:15 - 15:15 Concurrent Session 9: Macrophage and Iron Metabolism 
Chairs: Francesca Vinchi and Igor Theurl
Large Operon
14:15 - 14:30 Systemic dysfunction in Lysinuric Protein Intolerance drives immune complications
Susanna Bodoy - IRB Barcelona, Spain
14:30 - 14:45 Myeloid Heavy Chain Ferritin Mitigates Ischemic Acute Kidney Injury
Laurence Black - University of Alabama at Birmingham, United States of America
14:45 - 15:00 The macrophage iron phenotype – a novel target in cancer therapy?
Christina Mertens - University Hospital Heidelberg, Germany
15:00 - 15:15

Transfusion-induced impairment of macrophage responses is partially restored by the iron chelator deferasirox
Francesca Vinchi - New York Blood Center, United States of America

14:15 - 15:15

Concurrent Session 10: Iron Biology and Disease 
Chairs: Mayka Sanchez and Sonia Levi
ATC Courtyard Room A & B
14:15 - 14:30 Induction of erythroferrone in healthy humans by microdose recombinant erythropoietin or high altitude exposure
Elena Gammella - University of Milan, Italy
14:30 - 14:45 Iron Regulatory Protein 1 requires Glycogen Branching Enzyme and mitoNEET to remain functional as an iron-regulatory holo-form
Kirst King-Jones - University of Alberta, Canada
14:45 - 15:00 Title to be announced
Speaker to be announced
15:00 - 15:15 PIGA germline mutations may cause a novel subtype of hereditary hemochromatosis
Lena Muckenthaler - University of Heidelberg, Germany
15:15 - 16:00 Coffee Break ATC Auditorium Foyer
16:00 - 17:30 Concurrent Session 11: Iron Overload, Iron Chelation and Targeted Therapies 
Chairs: Robert Hider and Dorine Swinkels
ATC Auditorium
16:00 - 16:15 A New Orally Active Iron Chelator: CN128
Robert Hider - King's College London, United Kingdom
16:15 - 16:30 Applications of nanotechnology to the delivery of iron chelators
Greg Anderson - QIMR Berghofer Medical Research Institute, Australia
16:30 - 16:45

Orally-delivered Ginger Nanoparticle-derived Lipid Vectors Target Functional Dmt1 siRNAs to Duodenal Enterocytes and Mitigate Iron Loading in Hepcidin KO Mice
Xiaoyu Wang - University of Florida, United States of America

16:45 - 17:00

Title to be announced
Speaker to be announced

17:00 - 17:15 Novel third-generation ferrostatins protect against acute iron poisoning-induced organ injury
Samya Van Coillie -  Inflammation Research Center VIB-UGent, Belgium
17:15 - 17:30 Double knockout of ZIP14 and ZIP8 in mice reveals novel roles for ZIP8 in tissue iron accumulation in iron overload
Mitchell Knutson - University of Florida, United States of America
16:00 - 17:30 Concurrent Session 12: Cancer and Ferroptosis
Chairs: Monica Guzman and Marcus Conrad
Large Operon
16:00 - 16:30 MYCN mediates cysteine addiction and sensitizes to ferroptosis
Frank Westermann - German Cancer Research Center, Germany
16:30 - 16:45 Iron induces cell death and synergizes with anti-androgen therapy in prostate cancer pre-clinical models
Alessandro Campanella - San Raffaele Scientific Institute, Italy
16:45 - 17:00 Amyloid Precursor Protein (APP) Supports Tumorigenesis by Counteracting Iron-mediated Oxidative Stress and p38MAPK-dependent DNA Damage
Vivek Venkataramani - University Medical Center Göttingen, Germany
17:00 - 17:15 NCOA4 expression regulates ferritin accumulation and has differential effects on RSL3- and erastin-induced ferroptosis in HeLa cells
Magdalena Gryzik - University of Brescia, Italy
17:15 - 17:30 Pro-tumor characteristics of macrophage-derived lipocalin-2 (Lcn-2) are determined by its iron-load
Michaela Jung - Goethe-University Frankfurt, Germany
16:00 - 17:30 Concurrent Session 13: Tissue-Specific Regulation of Iron Metabolism
Chairs: Yelena Ginzburg and Katarzyna Mleczko-Sanecka
ATC Courtyard Room A & B
16:00 - 16:15 Intracellular iron deficiency in pulmonary arterial smooth muscle cells induces pulmonary arterial hypertension through endothelin-1
Samira Lakhal-Littleton - University of Oxford, United Kingdom
16:15 - 16:30 Mitoferrin 1/2 Deficiency in Type 2 Alveolar Epithelial Cells Aggravates Pulmonary Fibrosis
Suzanne M. Cloonan - Weill Cornell Medical College, United States of America
16:30 - 16:45 Iron regulatory protein 2 (IRP2) mediates resistive breathing-induced pulmonary inflammation
Theodoros Vassilakopoulos - McGill University, Canada
16:45 - 17:00 A Novel Role For Iron Regulatory Proteins In Hematopoiesis
Michael Bonadonna German Cancer Research Center, Germany
17:00 - 17:15 The role of hepatic transferrin in erythropoiesis
Yingying Yu - Zhejiang University School of Medicine, China
17:15 - 17:30 The iron-sensing receptor Tfr2 regulates osteoclastogenesis
Ulrike Baschant - TU Dresden, Medical Faculty, Germany
17:30 - 18:00 Meet the Master
Lawrie Powell
with refreshments
18:00 - 19:30 Dinner EMBL Canteen
19:30 - 22:00 Poster Session II (even numbers)
with drinks and snacks
ATC Helix A & B
Day 5 - Thursday 9 May 2019
TimeSpeakerLocation
07:45 - 08:45

Meet the Expert 5: DNA Biomarkers of Iron Disorders 
Domenico Girelli - University of Verona, Italy
Dorine Swinkels - Radboud University Nijmegen, The Netherlands

Students / trainees only - Space is limited, pre-registration essential. 
ATC Helix Seminar Room A
09:00 - 11:00 Plenary 4: Presidential Plenary Session with Top-Scoring Abstracts
Chairs: Ioav Cabantchik and Martina Muckenthaler

ATC Auditorium

(streamed to ATC Courtyard Room A & B)
09:00 - 09:20 Iron powers adaptive immune responses to immunisations and influenza virus
Joe Frost - University of Oxford, United Kingdom
09:20 - 09:40 A novel iron chaperone complex delivers iron to the cytosolic [2Fe-2S] cluster distribution system
Sarju Patel - National Institutes of Health, United States of America
09:40 - 10:00

Irp-Mediated Iron Homeostasis In Gut Epithelial Cells Limits Intestinal Tumorigenesis
Bruno Galy - German Cancer Research Center, Germany

10:00 - 10:20 Steroyl-CoA Desaturase 1 protects ovarian cancer cells from ferroptotic cell death
Suzy Torti - University of Connecticut Health Center, United States of America
10:20 - 10:40 Delineating heme transport using HRG1-deficient mouse models
Rini Pek - University of Maryland, United States of America
10:40 - 11:00 Ablation of hepatocyte Smad1, Smad5 and Smad8 causes severe tissue iron loading and liver fibrosis in mice
Chia-Yu Wang - Massachusetts General Hospital, United States of America
11:00 - 11:30 Coffee Break ATC Auditorium Foyer
11:30 - 13:00 Concurrent Session 14: Hereditary Hemochromatosis 
Chairs: Graça Porto and Pierre Brissot
ATC Auditorium
11:30 - 12:00 Ancient genomics and the origins of the European genome
Daniel Bradley - University of Dublin, Ireland 
12:00 - 12:15 The structure-function analysis of ferroportin 1 (FPN1) gating residues sheds new light on the pathogenic mechanisms involved in haemochromatosis type 4A (HC 4A)
Marlène Le Tertre - INSERM, France
12:15 - 12:30 Iron overload associated osteoporosis could be favored by a low level of hepcidin and/or by an alteration of Mn or Mo metabolisms
Olivier Loréal - INSERM, France
12:30 - 12:45 Penetrance of Hereditary Hemochromatosis mutations in 450,000 people of European Ancestry
David Melzer - University of Exeter Medical School, United Kingdom
12:45 - 13:00

Hemochromatosis: A Lower Illness with Higher Implications. A Rare Opportunity Of Following The Natural History Of An Age Related Disease
Graça Porto - Centro Hospitalar Universitário do Porto, Portugal

11:30 - 13:15 Concurrent Session 15: Therapeutic Approaches 
Chairs: Michael Zimmermann and Kostas Pantopoulos
Large Operon
11:30 - 11:45 The evolution of intravenous iron therapy
Carlo Gaillard - University of Utrecht, The Netherlands
11:45 - 12:00 Evaluation of the Intrinsic Hepcidin Idx™ To Detect Iron Deficiency (Id) In Adolescents and Young Adults
Mark Fleming - Boston Children's Hospital, United States of America
12:00 - 12:15 Oral iron therapy in predialysis Chronic Kidney Disease (CKD) patients has no adverse effects on the gut microbiome and circulating uremic toxin concentrations
Dorine Swinkels - Radboudumc, The Netherlands
12:15 - 12:30 Nanostructured Iron Compounds for Nutrition: Isotope Studies in DMT1-Knockout Mice and Thai Women
Hans Winkler - ETH Zürich, Switzerland
12:30 - 12:45 An Antisense Oligonucleotide (IONIS-TMPRSS6-LRX) Targeting Transmembrane Protease, Serine 6 (TMPRSS6) Induces Hepcidin and Reduces Serum Iron and Transferrin Saturation in Healthy Volunteers
Y Paul Goldberg - Ionis Pharmaceuticals, United States of America
12:45 - 13:00 SLN124, a GalNAc-siRNA Conjugate Targeting TMPRSS6, for the Treatment of Iron Overload and Ineffective Erythropoiesis Such as in Beta-Thalassemia
Ute Schaeper - Silence Therapeutics, Germany
13:00 - 13:15 Characterization of hepcidin and microglia in an Alzheimer mouse model
Andreas Popp - Abbvie Deutschland, Germany
11:30 - 13:00 Concurrent Session 16: Iron and Development 
Chairs: Elizabeta Nemeth and Nathan Subramaniam
ATC Courtyard Room A & B
11:30 - 11:45 Universal applicable serum hepcidin pediatric reference ranges: set point relative to body iron parameters changes during human growth and development
Albertine Donker - Radboudumc, The Netherlands
11:45 - 12:00 Iron Transport to the Fetus is Controlled by a ‘Selfish’ Placenta
Veena Sangkhae - University of California, Los Angeles, United States of America
12:00 - 12:15 Maternal Iron Excess and Inflammation during Pregnancy Synergize to Cause Embryotoxicity
Allison Fisher -  University of California, Los Angeles, United States of America
12:15 - 12:30 Iron and n-3 fatty acid depletion, alone and in combination, during early development provoke anxiety, hedonic and social dysfunction in rats
Jeannine Baumgartner - ETH Zurich, Switzerland
12:30 - 12:45 Behavioral effects of excess ferrous sulfate or ferrous bisglycinate chelate supplementation on suckling rat pups
Shasta McMillen - University of California, Davis, United States of America
12:45 - 13:00 The Regulation of Cellular Heme Metabolism Is Crucial For Neurodevelopment
Deborah Chiabrando - University of Torino, Italy
13:00 - 14:30 Lunch ATC Auditorium Foyer
14:30 - 15:30 Business Meeting
for members of the International BioIron Society
ATC Auditorium
15:30 - 16:30 Hemochromatosis Nomenclature Meeting ATC Courtyard Room A & B
16:30 - 18:00 Joint European Federation of Associations of Patients with Haemochromatosis (EFAPH) and Haemochromatosis International (HI) Annual General Meeting Large Operon
16:30 - 18:30 Free Time
18:30 - 19:30 Social Hour
with refreshments
ATC Auditorium Foyer
19:30 - 21:30 Farewell Dinner with Award Ceremony EMBL Canteen
21:30 - 01:00 Party with Live Bands
Opening Act: The Iron-Balls
Headliner: The Wright Thing
ATC Auditorium Foyer
Day 6 - Friday 10 May 2019
(International Haemochromatosis Patients Meeting)
TimeSpeakerLocation
08:30 - 09:30 What's New ATC Courtyard A & B
09:30 - 10:15 The Impact of Research on Diagnosis and Therapy of Haemochromatosis Patients ATC Courtyard A & B
10:15 - 10:35 Coffee Break
10:35 - 11:20 Haemochromatosis Arthropathy (HARI Group) ATC Courtyard A & B
11:20 - 11:35 Haemochromatosis Nomenclature Update ATC Courtyard A & B
11:35 - 12:20 Review of 2018 by EFAPH and HI Member Associations ATC Courtyard A & B
12:20 - 13:20 Lunch
13:20 - 16:00 Updates and Future Projects ATC Courtyard A & B
16:00 - 16:30 Concluding Remarks ATC Courtyard A & B