Location & dates EMBL Heidelberg, Germany 5 - 10 May 2019
Deadlines Registration closed Abstract submission closed
Organiser_IBIS

Programme

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Day 1 - Sunday 5 May 2019
(Educational Day, Keynote Lecture and Welcome Reception)
TimeSpeakerLocation
Introductory Course: Iron Essentials for Clinicians and Scientists
Coordinated by Jodie Babitt, Hal Drakesmith and Ioav Cabantchik
08:00 - 09:00 Arrival and Registration for Educational Day
with light refreshments
ATC Registration Desk
09:00 - 18:00

Introductory Course: Iron Essentials for Clinicians and Scientists
Coordinated by Jodie Babitt, Ioav Cabantchik and Hal Drakesmith

ATC Auditorium
09:00 - 09:05 Introductory Remarks 
Ioav Cabantchik, President IBIS - Hebrew University of Jerusalem, Israel
ATC Auditorium
09:05 - 12:30 Session 1: Basic Properties and Methodologies 
Chairs: Greg Anderson and Robert Fleming 
ATC Auditorium
09:05 - 09:45 BioIron: Origin, chemical properties and evolution
Kostas Pantopoulos - McGill University, Canada
09:45 - 10:30 Iron transport proteins: Gateways of cellular and systemic iron homeostasis 
Mitchell Knutson - University of Florida, United States of America
10:30 - 11:00 Coffee Break  ATC Auditorium Foyer
11:00 - 12:30 Session 1: Basic Properties and Methodologies (continued)
Chairs: Greg Anderson and Robert Fleming 
ATC Auditorium
11:00 - 11:45 Mechanisms controlling cellular iron homeostasis in mammals 
Rick Eisenstein - University of Wisconsin-Madison, United States of America
11:45 - 12:30 Systemic iron homeostasis 
Jodie Babitt - Massachusetts General Hospital, Harvard Medical School, United States of America
12:30 - 13:30 Lunch EMBL Canteen
13:30 - 15:30 Session 2: Genetic and Acquired Iron Disorders
Chairs: Clara Camaschella and Günter Weiss
ATC Auditorium
13:30 - 14:00 Genetic diseases causing iron deficiency and iron overload: Two faces of the same coin 
Laura Silvestri - San Raffaele Scientific Institute, Italy
14:00 - 14:30 Erythropoiesis and iron metabolism: Crosstalk, implications, and therapeutic options in iron loading anemias 
Yelena Ginzburg - Icahn School of Medicine at Mount Sinai, United States of America
14:30 - 15:30 Iron in cancer, infection, kidney and liver diseases: Innocent bystander or therapeutic target? 
Igor Theurl and Heinz Zoller - Medical University of Innsbruck, Austria
15:30 - 16:00 Coffee Break ATC Auditorium Foyer
16:00 - 17:30 Session 3: Global Issues
Chairs: Domenico Girelli and Dorine Swinkels
ATC Auditorium
16:00 - 16:45 The pathophysiology and diagnosis of iron deficiency and anaemia in populations and patients 
Sant-Rayn Pasricha - Walter and Eliza Hall Institute, Australia
16:45 - 17:30 Nutritional (dietary) and "functional" deficiencies in the first and third world 
Michael Zimmermann - ETH Zürich, Switzerland
17:30 - 18:00 Session 4: The Future of BioIron
Chair: Hal Drakesmith
ATC Auditorium
17:30 - 18:00 Open questions in basic and clinical iron research
"It is hard to make predictions, especially about the future." -- Yogi Berra

Tomas Ganz and Elizabeta Nemeth - University of California, Los Angeles, United States of America
17:30 - 18:30 Arrival and Registration for Keynote Lecture and Welcome Reception
with light refreshment
ATC Registration Desk
18:30 - 19:30 Keynote Lecture: Analyzing microbiomes in us and on our planet
Peer Bork - EMBL Heidelberg, Germany
ATC Auditorium
19:30 - 21:30 Welcome Reception
with nibbles and refreshments
ATC Auditorium Foyer
Day 2 - Monday 6 May 2019
TimeSpeakerLocation
08:00 - 08:45 Arrival and Registration
with light refreshments
ATC Registration Desk
08:45 - 09:00 Welcome Remarks 
by organisers Ioav Cabantchik - Hebrew University of Jerusalem, Israel
Matthias Hentze - EMBL Heidelberg, Germany
Martina Muckenthaler - University of Heidelberg, Germany

ATC Auditorium

(streamed to ATC Courtyard Room A & B)
09:00 - 12:30 Plenary 1: Cell Biology of Iron Metabolism 
Chairs: Bruno Galy and Matthias Hentze

ATC Auditorium

(streamed to ATC Courtyard Room A & B)
09:00 - 09:30 Mechanisms of ferroptosis
Marcus Conrad - Helmholtz Zentrum München, Germany
09:30 - 09:45 Mechanisms, pathways and regulation of mammalian ferritin secretion
Lior Spektor - Technion - Israel Institute of Technology, Israel
09:45 - 10:00 Novel mechanistic insights into the regulation of BMP-SMAD pathway and hepcidin expression by FKBP12
Alessandro Dulja -  San Raffaele Scientific Institute, Italy
10:00 - 10:15 A novel role for peroxisomal proteins in iron homeostasis
Nathan Subramaniam - Queensland University of Technology, Australia
10:15 - 10:30 A systems genetics approach to identify genes and pathways involved in liver iron overload and pathology
Brie Fuqua - University of California, Los Angeles, United States of America
10:30 - 11:00 Coffee Break ATC Foyer
11:00 - 12:30 Plenary 1: Cell Biology of Iron Metabolism (continued)
Chairs: Mitchell Knutson and Marie-Paule Roth

ATC Auditorium

(streamed to ATC Courtyard Room A & B)
11:00 - 11:30 Transferrin receptor 2 controls bone mass and pathological bone formation via BMP and Wnt signaling
Martina Rauner - TU Dresden Medical Center, Germany
11:30 - 12:00 Regulation of transferrin receptor via S-acylation
Aurelio Teleman - German Cancer Research Center, Germany
12:00 - 12:15 Ncoa4-mediated ferritinophagy maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms
Joseph Mancias - Dana-Farber Cancer Institute, United States of America
12:15 - 12:30

PCBP1-mediated iron binding and delivery in the cytosol: mechanisms and impacts
Caroline Philpott -  National Institutes of Health, United States of America

12:30 - 14:00 Lunch ATC Auditorium Foyer
14:00 - 15:30 Concurrent Session 1: Iron Deficiency in Cancer Patients: A Clinical Perspective
Chairs: Max Gassmann and Andrea Steinbicker
ATC Auditorium
14:00 - 14:20 Iron deficiency in cancer patients: An emerging issue but difficult to define
Domenico Girelli - University of Verona, Italy
14:20 - 14:40 Management of anemia and iron deficiency in cancer patients: What guidelines say?
Manuel Muñoz - University of Málaga, Spain
14:40 - 15:00 Perioperative anemia and iron deficiency in oncological surgery
Donat Spahn - University Hospital Zürich, Switzerland
15:00 - 15:30 Round Table Discussion ATC Auditorium
14:00 - 15:30 Concurrent Session 2: Erythropoiesis and Iron 
Chairs: Robert Fleming and Antonella Nai
Large Operon
14:00 - 14:30 Gene therapy to cure hemoglobinopathies
Marina Cavazzana - Hôpital Necker - Enfants Malades, France

14:30 - 14:45

Combining Tfr2-haploinsufficiency with TMPRSS6-antisense oligonucleotides strongly ameliorates the hematological phenotype of thalassemic mice
Antonella Nai - San Raffaele Scientific Institute, Italy
14:45 - 15:00 The regulation of ferroportin and iron regulatory protein 2 on erythropoiesis
Deliang Zhang - National Institutes of Health, United States of America
15:00 - 15:15 The role of glutathione peroxidase 4 and vitamin E in reticulocyte maturation and iron homeostasis
Georg W. Bornkamm - Helmholtz Zentrum München, Germany
15:15 - 15:30 AMPK regulates the expression of the Fe-S cluster assembly enzyme (ISCU) and ALAS2, modulating cellular iron metabolism and increasing hemoglobin synthesis
Ping La - Children's Hospital of Philadelphia, United States of America
14:00 - 15:30 Concurrent Session 3: Heme Physiology and Pathophysiology 
Chairs: Iqbal Hamza and Emanuela Tolosano
ATC Courtyard Room A & B
14:00 - 14:15 The safe coordinated trafficking of heme and iron after heme-hemopexin endocytosis requires copper for cell homeostasis
Ann Smith - University of Missouri, United States of America
14:15 - 14:30 Heme cytotoxicity in the brain: Microglia polarization and neuronal damage
Illyane Lima - NOVA University Lisbon, Portugal
14:30 - 14:45 Iron deposition associated to vascular damage and hemolysis causes senescence and fibrosis
Mate Maus - IRB Barcelona, Barcelona Institute of Science and Technology, Spain
14:45 - 15:00 Modulating heme biosynthesis alters Toxoplasma sensitivity to antimalarials
Clare Harding - University of Glasgow, United Kingdom
15:00 - 15:15 Metabolic adaptation in colorectal cancer: Heme export is required for the modulation of the tricarboxylic acid cycle
Veronica Fiorito - University of Turin, Italy
15:15 - 15:30 Heme synthesis/Heme export axis as a novel regulator of cellular oxidative metabolism
Emanuela Tolosano - University of Turin, Italy
15:30 - 16:00 Coffee Break ATC Auditorium Foyer
16:00 - 17:30 Concurrent Session 4: Infection and Inflammation 
Chairs: Caroline Philpott and Günter Weiss
ATC Auditorium
16:00 - 16:15 Non-transferrin-bound iron in hematopoietic stem cell transplanted patients serves as iron source for Aspergillus fumigatus outgrowth
Verena Petzer - Medical University of Innsbruck, Austria
16:15 - 16:30 Reduction in erythrocyte life span as a key component of mycobacteria induced anemia
Maria Salomé Gomes - University of Porto, Portugal
16:30 - 16:45 The role of TNFa and IFNg in anemia of inflammation, immunity and stress erythropoiesis
Stefano Rivella - Children's Hospital of Philadelphia, United States of America
16:45 - 17:00 Hepcidin-mediated hypoferremic response to acute inflammation requires a threshold of Bmp6/Hjv/Smad signaling
Edouard Charlebois - McGill University, Canada
17:00 - 17:15 Hemolysis and intracellular heme confer protection against anti-CD40-triggered macrophage activation syndrome and vaso-occlusive inflammatory liver disease
Giada Ingoglia - University of Zürich, Switzerland
17:15 - 17:30 Anemia in infants at age 10-24 weeks predicts reduced long-term efficacy of diphtheria vaccine: a 2-year prospective observational study in rural Kenya
Nicole Stoffel - ETH Zürich, Switzerland
16:00 - 17:30 Concurrent Session 5: Liver Iron-Sensing and Control of the Hepcidin/Ferroportin Regulatory System
Chairs: Laura Silvestri and Jodie Babitt
Large Operon
16:00 - 16:30 New modes of hepcidin regulation
Hal Drakesmith - University of Oxford, United Kingdom
16:30 - 16:45 Endothelial Bmp2 knockout exacerbates hemochromatosis in Hfe knockout mice but not Bmp6 knockout mice
Xia Xiao - Massachusetts General Hospital, Harvard Medical School, United States of America
16:45 - 17:00 The hemochromatosis proteins are dispensable for acute BMP2-mediated hepcidin upregulation in mice
Alessia Pagani - San Raffaele Scientific Institute, Italy
17:00 - 17:15 MyD88 regulates the expression of SMAD4 and the iron regulatory hormone hepcidin
Macha Samba Mondonga - University of Montreal, Canada
17:15 - 17:30 Spatial zonation of hepcidin in the liver is patterned by testosterone
Hélène Coppin - INSERM, France
16:00 - 17:30 Concurrent Session 6: Iron and Neurodegeneration 
Chairs: Ashley Bush and Raffaella Gozzelino
ATC Courtyard Room A & B
16:00 - 16:30 Is ferroptosis, a newly characterized iron-dependent form of cell death, a clue for neuroprotection in Parkinson's disease?
David Devos - University of Lille, France
16:30 - 16:45 Evidence for communication between systemic iron status and cerebrospinal fluid:  Clinical implications for therapeutic strategy
James Connor - Pennyslvania State University, United States of America
16:45 - 17:00 Mitochondrial ferritin attenuates ferroptosis and ER-stress induced apoptosis in an experimental model of ischemic stroke
Peina Wang - Hebei Normal University, China
17:00 - 17:15 How and why does iron storage fail with age?
Gawain McColl - University of Melbourne, Australia
17:15 - 17:30 Changes in gut microbiota: An early event in Parkinson’s disease
Raffaella Gozzelino - NOVA University of Lisbon, Portugal
16:00 - 17:30 Concurrent Session 7: Iron Deficiency Disorders and Their Treatment
Chairs: Diego Moretti and Heinz Zoller
Small Operon
16:00 - 16:15 The effect of genetic variation in TMPRSS6 (SNP rs855791) on iron metabolism and oral iron absorption: a stable iron isotope study in Taiwanese women
Sung-Nan Pei - Chia-Yi Chang Gung Memorial Hospital, Taiwan
16:15 - 16:30 Tmprss6-/- mice show plasma FGF23 elevation that is influenced by Fgf23 gene dosage
Xiuqi Li - Yale School of Medicine, United States of America
16:30 - 16:45 Generation and development of KY1070, a fully human anti-BMP6 antibody for treatment of Anemia of Chronic Disease
Volker Germaschewski - Kymab, United Kingdom
16:45 - 17:00 Iron deficiency and a genetic risk score derived from GWAS are associated with Restless Legs Syndrome and its severity in 20,000 blood donors
David J. Roberts - University of Oxford, United Kingdom
17:00 - 17:15 Novel formulations to fortify rice with iron: Evidence and public health potential
Diego Moretti - Swiss Distance University of Applied Sciences, Switzerland
17:15 - 17:30 Fecal microbiota as a biomarker to predict the tissue iron accumulation in intestine epithelial cells and liver
Liwei Xie - Guangdong Institute of Microbiology, China
17:30 - 18:00

Meet the Master 
Interview with Maria de Sousa
with refreshments
Presenter: Ioav Cabantchik

ATC Auditorium Foyer Stage
18:00 - 19:30 Dinner  EMBL Canteen
19:30 - 20:30

Open Debate: Controversies in Bioiron
Topic: Intravenous Iron Supplementation in Chronic Cardiac Failure
Moderator: Tomas Ganz
In Favor: Iain Macdougall - King's College Hospital, United Kingdom
Against: Hossein Ardehali - Northwestern University, United States of America

ATC Courtyard A & B
19:30 - 22:00 Poster Session I (odd numbers)
with drinks and snacks
ATC Helix A & B
Day 3 - Tuesday 7 May 2019
TimeSpeakerLocation
07:45 - 08:45

Meet the Expert 1: Gene Therapy for Iron Disorders
Stefano Rivella - University of Pennsylvania, United States of America

Concurrent sessions. Students / trainees only - Space is limited, pre-registration essential.

ATC Helix Seminar Room A
07:45 - 08:45

Meet the Expert 2: Tracing the Intracellular Dynamics of Iron and Heme
Iqbal Hamza - University of Maryland, United States of America

Concurrent sessions. Students / trainees only - Space is limited, pre-registration essential.

ATC Helix Seminar Room B
09:00 - 12:30 Plenary 2: Disorders of Iron Metabolism
Chairs: Clara Camaschella and Antonello Pietrangelo
ATC Auditorium

(streamed to ATC Courtyard Room A & B)

09:00 - 09:30 The battle for iron between pathogens, the host, and the microbiota in the inflamed gut
Manuela Raffatellu -  University of California, San Diego, United States of America
09:30 - 10:00 Ferritinophagy and cell cycle control
Francesca Carlomagno - University of Naples Federico II, Italy
10:00 - 10:15 The natural history of ferroportin Ddsease – first results of the international, multicenter non-HFE registry
Benedikt Schaefer - Medical University of Innsbruck, Austria
10:15 - 10:30 New insights into the molecular mechanisms underlying the pro-atherosclerotic effect of non-transferrin-bound iron
Francesca Vinchi - New York Blood Center, United States of America
10:30 - 11:00 Coffee Break ATC Auditorium Foyer
11:00 - 12:30 Plenary 2: Disorders of Iron Metabolism (continued)
Chairs: Tomas Ganz and Stefano Rivella
ATC Auditorium

(streamed to ATC Courtyard Room A & B)

11:00 - 11:30 Treating leukemia with oxidative ferrotherapy
Monica Guzman - Cornell University, United States of America
11:30 - 12:00 Iron, ferroptosis, aging and Alzheimer’s disease
Ashley Bush - The Florey Institute of Neuroscience and Mental Health, Australia
12:00 - 12:15 Differential effects of IRP1 deficiency versus HIF-2a IRE deletion on postnatal erythropoiesis in mice
Rick Eisenstein - University of Wisconsin-Madison, United States of America
12:15 - 12:30 Absence of iron-responsive element-binding protein 2 causes a novel neurodegenerative syndrome
Nunziata Maio - National Institutes of Health, United States of America
12:30 Packed Lunch  ATC Auditorium Foyer
From 12:30 Free Afternoon
19:00 - 20:30 Drinks Reception with Live Music Blue Note Jazz Trio
Ticketed event. Heidelberg Castle
Heidelberg Castle
Day 4 - Wednesday 8 May 2019
TimeSpeakerLocation
07:45 - 08:45

Meet the Expert 3: Translating Biologic Discoveries to Clinical Practice
Tomas Ganz - University of California, Los Angeles, United States of America
Elizabeta Nemeth - University of California, Los Angeles, United States of America

Concurrent sessions. Students / trainees only - Space is limited, pre-registration essential
ATC Helix Seminar Room A
07:45 - 08:45

Meet the Expert 4: Biophysical Approaches to Iron Speciation in Cells and Organ Development
Robert Hider - King's College London, United Kingdom
Paul Lindahl - Texas A&M University, United States of America

Concurrent sessions. Students / trainees only - Space is limited, pre-registration essential.
ATC Helix Seminar Room B
09:00 - 12:30

Plenary 3: Biology of Iron-Sulfur Proteins
Chairs: Roland Lill* and Ioav Cabantchik

(* COST Action 15133 "The Biogenesis of Iron-sulfur Proteins: from Cellular Biology to Molecular Aspects (FeSBioNet))

ATC Auditorium

(streamed to ATC Courtyard Room A & B)
09:00 - 09:30 Iron homeostasis regulates facultative heterochromatin assembly in adaptive genome control
Shiv Grewal - National Institutes of Health, United States of America
09:30 - 10:00 Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification
Elisabeth Leibold - University of Utah, United States of America
10:00 - 10:30 Friedreich ataxia: role of frataxin and pathophysiological consequences
Hélène Puccio* - INSERM, France
10:30 - 11:00 Coffee Break ATC Auditorium Foyer
11:00 - 12:30

Plenary 3: Biology of Iron-Sulfur Proteins (continued)
Chairs: Tracey Rouault and Caroline Enns

(* COST Action 15133 "The Biogenesis of Iron-sulfur Proteins: from Cellular Biology to Molecular Aspects (FeSBioNet))

ATC Auditorium

(streamed to ATC Courtyard Room A & B)
11:00 - 11:30 Cytosolic and nuclear iron-sulfur protein assembly
Oliver Stehling* - Philipps University of Marburg, Germany
11:30 - 12:00 The lability of the NEET proteins' iron sulphur cluster: Biomedical implication
Rachel Nechushtai* - Hebrew University of Jerusalem, Israel
12:00 - 12:15 Fe-S cluster biogenesis in DNA repair proteins: Structural studies of the CIA machinery
Susanne Kassube - Friedrich Miescher Institute for Biomedical Research, Switzerland
12:15 - 12:30 Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis
Nunziata Maio - National Institutes of Health, United States of America
12:30 - 14:15 Lunch  ATC Auditorium Foyer
14:15 - 15:15 Concurrent Session 8: Cardiovascular Disease 
Chairs: Hossein Ardehali and Samira Lakhal-Littleton
ATC Auditorium
14:15 - 14:30 Unexpected differences in cardiac iron metabolism and survival in Hepcidin-ko and FpnC326S mice
Sandro Altamura - Heidelberg University, Germany
14:30 - 14:45 Role of mTOR-TTP Pathway in cardiac response to iron deficiency
Hossein Ardehali - Northwestern University, United States of America
14:45 - 15:00 Smooth muscle cell iron retention contributes to the pathology of abdominal aortic aneurysm
Paul Loick - University of Oxford, United Kingdom
15:00 - 15:15 Interfering with endothelial heme metabolism to control the angiogenic process
Sara Petrillo - University of Turin, Italy
14:15 - 15:15 Concurrent Session 9: Macrophage and Iron Metabolism 
Chairs: Igor Theurl and Francesca Vinchi 
Large Operon
14:15 - 14:30 Systemic dysfunction in Lysinuric Protein Intolerance drives immune complications
Susanna Bodoy - IRB Barcelona, Spain
14:30 - 14:45 Myeloid heavy chain ferritin mitigates ischemic acute kidney injury
Laurence Black - University of Alabama at Birmingham, United States of America
14:45 - 15:00 The macrophage iron phenotype – a novel target in cancer therapy?
Christina Mertens - Heidelberg University Hospital, Germany
15:00 - 15:15

Transfusion-induced impairment of macrophage responses is partially restored by the iron chelator deferasirox
Francesca Vinchi - New York Blood Center, United States of America

14:15 - 15:15

Concurrent Session 10: Iron Biology and Disease 
Chairs: Sonia Levi and Mayka Sanchez 
ATC Courtyard Room A & B
14:15 - 14:30 Induction of erythroferrone in healthy humans by microdose recombinant erythropoietin or high altitude exposure
Elena Gammella - University of Milan, Italy
14:30 - 14:45 Iron Regulatory Protein 1 requires glycogen branching enzyme and mitoNEET to remain functional as an iron-regulatory holo-form
Kirst King-Jones - University of Alberta, Canada
14:45 - 15:00 TGFß regulates BMP2 in liver sinusoidal endothelial cells: A possible link between chronic liver disease and iron overload
Silvia Colucci - Heidelberg University, Germany
15:00 - 15:15 PIGA germline mutations may cause a novel subtype of hereditary hemochromatosis
Lena Muckenthaler - Heidelberg University, Germany
15:15 - 16:00 Coffee Break ATC Auditorium Foyer
16:00 - 17:30 Concurrent Session 11: Iron Overload, Iron Chelation and Targeted Therapies 
Chairs: Robert Hider and Dorine Swinkels
ATC Auditorium
16:00 - 16:15 A new orally active iron chelator: CN128
Robert Hider - King's College London, United Kingdom
16:15 - 16:30 Applications of nanotechnology to the delivery of iron chelators
Greg Anderson - QIMR Berghofer Medical Research Institute, Australia
16:30 - 16:45

Orally-delivered ginger nanoparticle-derived lipid vectors target functional Dmt1 siRNAs to duodenal enterocytes and Mitigate Iron Loading in Hepcidin KO Mice
Xiaoyu Wang - University of Florida, United States of America

16:45 - 17:00

Gastrointestinal iron excretion and reversal of iron excess in a mouse model of inherited iron excess
Thomas Bartnikas - Brown University, United States of America

17:00 - 17:15 Novel third-generation ferrostatins protect against acute iron poisoning-induced organ injury
Samya Van Coillie -  VIB-UGent, Belgium
17:15 - 17:30 Double knockout of ZIP14 and ZIP8 in mice reveals novel roles for ZIP8 in tissue iron accumulation in iron overload
Mitchell Knutson - University of Florida, United States of America
16:00 - 17:30 Concurrent Session 12: Cancer and Ferroptosis
Chairs: Marcus Conrad and Monica Guzman 
Large Operon
16:00 - 16:30 MYCN mediates cysteine addiction and sensitizes to ferroptosis
Frank Westermann - German Cancer Research Center, Germany
16:30 - 16:45 Iron induces cell death and synergizes with anti-androgen therapy in prostate cancer pre-clinical models
Alessandro Campanella - San Raffaele Scientific Institute, Italy
16:45 - 17:00 Amyloid precursor protein (APP) supports tumorigenesis by counteracting iron-mediated oxidative stress and p38MAPK-dependent DNA damage
Vivek Venkataramani - University Medical Center Göttingen, Germany
17:00 - 17:15 NCOA4 expression regulates ferritin accumulation and has differential effects on RSL3- and erastin-induced ferroptosis in HeLa cells
Magdalena Gryzik - University of Brescia, Italy
17:15 - 17:30 Pro-tumor characteristics of macrophage-derived lipocalin-2 (Lcn-2) are determined by its iron-load
Michaela Jung - Goethe-University Frankfurt, Germany
16:00 - 17:30 Concurrent Session 13: Tissue-Specific Regulation of Iron Metabolism
Chairs: Yelena Ginzburg and Katarzyna Mleczko-Sanecka
ATC Courtyard Room A & B
16:00 - 16:15 Intracellular iron deficiency in pulmonary arterial smooth muscle cells induces pulmonary arterial hypertension through endothelin-1
Samira Lakhal-Littleton - University of Oxford, United Kingdom
16:15 - 16:30 Mitoferrin 1/2 Deficiency in Type 2 Alveolar epithelial cells aggravates pulmonary fibrosis
Suzanne M. Cloonan - Weill Cornell Medical College, United States of America
16:30 - 16:45 Iron regulatory protein 2 (IRP2) mediates resistive breathing-induced pulmonary inflammation
Kostas Pantopoulos - McGill University, Canada
16:45 - 17:00 A novel role for iron regulatory proteins in hematopoiesis
Michael Bonadonna German Cancer Research Center, Germany
17:00 - 17:15 The role of hepatic transferrin in erythropoiesis
Yingying Yu - Zhejiang University School of Medicine, China
17:15 - 17:30 The iron-sensing receptor Tfr2 regulates osteoclastogenesis
Ulrike Baschant - TU Dresden, Germany
17:30 - 18:00 Meet the Master
Interview with Lawrie Powell
with refreshments
Presenter: Greg Anderson
ATC Auditorium Foyer Stage
18:00 - 19:30 Dinner EMBL Canteen
19:30 - 22:00 Poster Session II (even numbers)
with drinks and snacks
ATC Helix A & B
Day 5 - Thursday 9 May 2019
TimeSpeakerLocation
07:45 - 08:45

Meet the Expert 5: DNA Biomarkers of Iron Disorders 
Domenico Girelli - University of Verona, Italy
Dorine Swinkels - Radboud University, The Netherlands

Students / trainees only - Space is limited, pre-registration essential. 
ATC Helix Seminar Room A
09:00 - 11:00 Plenary 4: Presidential Plenary Session with Top-Scoring Abstracts
Chairs: Ioav Cabantchik and Martina Muckenthaler

ATC Auditorium

(streamed to ATC Courtyard Room A & B)
09:00 - 09:20 Iron powers adaptive immune responses to immunisations and influenza virus
Joe Frost - University of Oxford, United Kingdom
09:20 - 09:40 A novel iron chaperone complex delivers iron to the cytosolic [2Fe-2S] cluster distribution system
Sarju Patel - National Institutes of Health, United States of America
09:40 - 10:00

IRP mediated iron homeostasis in gut epithelial cells limits intestinal tumorigenesis
Bruno Galy - German Cancer Research Center, Germany

10:00 - 10:20 Steroyl-CoA Desaturase 1 protects ovarian cancer cells from ferroptotic cell death
Suzy Torti - University of Connecticut Health Center, United States of America
10:20 - 10:40 Delineating heme transport using HRG1-deficient mouse models
Iqbal Hamza - University of Maryland, United States of America
10:40 - 11:00 Ablation of hepatocyte Smad1, Smad5 and Smad8 causes severe tissue iron loading and liver fibrosis in mice
Chia-Yu Wang - Massachusetts General Hospital, United States of America
11:00 - 11:30 Coffee Break ATC Auditorium Foyer
11:30 - 13:00 Concurrent Session 14: Hereditary Hemochromatosis 
Chairs: Pierre Brissot and Graça Porto
ATC Auditorium
11:30 - 12:00 Ancient genomics and the origins of the European genome
Daniel Bradley - Trinity College Dublin, Ireland 
12:00 - 12:15 The structure-function analysis of ferroportin 1 (FPN1) gating residues sheds new light on the pathogenic mechanisms involved in haemochromatosis type 4A (HC 4A)
Marlène Le Tertre -University Hospital Brest , France
12:15 - 12:30 Iron overload associated osteoporosis could be favored by a low level of hepcidin and/or by an alteration of Mn or Mo metabolisms
Olivier Loréal - INSERM, France
12:30 - 12:45 Penetrance of hereditary hemochromatosis mutations in 450,000 people of European ancestry
David Melzer - University of Exeter Medical School, United Kingdom
12:45 - 13:00

Hemochromatosis: A lower illness with higher implications. A rare opportunity of following the natural history of an age related disease
Graça Porto - University of Porto, Portugal

11:30 - 13:15 Concurrent Session 15: Therapeutic Approaches 
Chairs: Kostas Pantopoulos and Michael Zimmermann
Large Operon
11:30 - 11:45 The evolution of intravenous iron therapy
Carlo Gaillard - University of Utrecht, The Netherlands
11:45 - 12:00 Evaluation of the intrinsic Hepcidin Idx™ to detect iron deficiency (Id) in adolescents and young adults
Mark Fleming - Boston Children's Hospital, United States of America
12:00 - 12:15 Oral iron therapy in predialysis Chronic Kidney Disease (CKD) patients has no adverse effects on the gut microbiome and circulating uremic toxin concentrations
Dorine Swinkels - Radboud University Medical Center, The Netherlands
12:15 - 12:30 Nanostructured iron compounds for nutrition: Isotope studies in DMT1-knockout mice and Thai women
Hans Winkler - ETH Zürich, Switzerland
12:30 - 12:45 An antisense Oligonucleotide (IONIS-TMPRSS6-LRX) targeting transmembrane protease, Serine 6 (TMPRSS6) induces hepcidin and reduces serum iron and transferrin saturation in healthy volunteers
Y Paul Goldberg - Ionis Pharmaceuticals, United States of America
12:45 - 13:00 SLN124, a GalNAc-siRNA conjugate targeting TMPRSS6, for the treatment of iron overload and Iieffective erythropoiesis such as in beta thalassemia
Ute Schaeper - Silence Therapeutics GmbH, Germany
13:00 - 13:15 Characterization of hepcidin and microglia in an Alzheimer mouse model
Andreas Popp - Abbvie Deutschland, Germany
11:30 - 13:00 Concurrent Session 16: Iron and Development 
Chairs: Elizabeta Nemeth and Nathan Subramaniam
ATC Courtyard Room A & B
11:30 - 11:45 Universal applicable serum hepcidin pediatric reference ranges: set point relative to body iron parameters changes during human growth and development
Albertine Donker - Radboud University Medical Center, The Netherlands
11:45 - 12:00 Iron transport to the fetus is controlled by a ‘Selfish’ placenta
Veena Sangkhae - University of California, Los Angeles, United States of America
12:00 - 12:15 Maternal iron excess and inflammation during pregnancy synergize to cause embryotoxicity
Allison Fisher -  University of California, Los Angeles, United States of America
12:15 - 12:30 Iron and n-3 fatty acid depletion, alone and in combination, during early development provoke anxiety, hedonic and social dysfunction in rats
Jeannine Baumgartner - ETH Zürich, Switzerland
12:30 - 12:45 Behavioral effects of excess ferrous sulfate or ferrous bisglycinate chelate supplementation on suckling rat pups
Shasta McMillen - University of California, Davis, United States of America
12:45 - 13:00 The regulation of cellular heme metabolism is crucial for deurodevelopment
Deborah Chiabrando - University of Turin, Italy
13:00 - 14:30 Lunch ATC Auditorium Foyer
14:30 - 18:30 Free Time
14:30 - 15:30 Business Meeting
for members of the International BioIron Society
ATC Auditorium
15:30 - 16:30 Hemochromatosis Nomenclature Meeting ATC Courtyard Room A & B
16:30 - 18:00 Joint European Federation of Associations of Patients with Haemochromatosis (EFAPH) and Haemochromatosis International (HI) Annual General Meeting Large Operon
18:30 - 19:30 Social Hour
with refreshments
ATC Auditorium Foyer
19:30 - 21:30 Farewell Dinner with Award Ceremony EMBL Canteen
21:30 - 01:00 Party with Live Bands
Opening Act: The Iron-Balls
Headliner: The Wright Thing
ATC Auditorium Foyer
Day 6 - Friday 10 May 2019
(International Haemochromatosis Patients Meeting)
TimeSpeakerLocation
08:30 - 09:30

What's New

  • What is new in HH? Report from the BioIron Meeting 2019 (Prof. Mayka Sanchez) (15 min)
  • Innovative approaches in HH-therapy (Prof. Pierre Brissot) (15 min)
  • Update of the EuroBloodNet activities (Prof. Graça Porto) (15 min)
  • Discussion of three previous presentations (15 min)
ATC Courtyard A
09:30 - 10:15 The Impact of Research on Diagnosis and Therapy of Haemochromatosis Patients (Prof. Paul Adams)
ATC Courtyard A
10:15 - 10:35 Coffee Break Foyer Courtyard
10:35 - 11:20

Haemochromatosis Arthropathy (HARI Group)

  • Update on HARI’s projects (Dr. Patrick Kiely) (20 min)
  • Outcome of ankle joint replacement (Dr.Axel Braner ) (10 min)
  • Questions to previous two presentations (15 min)
ATC Courtyard A
11:20 - 11:35 Haemochromatosis Nomenclature Update (Prof. Pierre Brissot)
ATC Courtyard A
11:35 - 12:20 Review of 2018 by EFAPH and HI Member Associations (F. Courtois – D. Prince)
ATC Courtyard A
12:20 - 13:20 Lunch EMBL Canteen
13:20 - 16:00

Updates and Future Projects

  • The future of EFAPH / HI: Towards a closer partnership (Howard Don, Ketil Toska) (20 min)
  • World Haemochromatosis Week 2019 (June Saturday 1st – Sunday 9th) and 2020?  (15 min)
  • Future projects continued & agreed actions (45 min) (Dianne Prince, Ketil Toska)
  • Other issues
ATC Courtyard A
16:00 - 16:30 Concluding Remarks (New presidents of EFAPH and HI)
ATC Courtyard A