Location & dates EMBL Heidelberg, Germany 28 - 30 May 2019
Deadlines Registration closed Abstract submission closed

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Programme

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Day 1 - Tuesday 28 May 2019
TimeSpeaker
09:00 - 10:45 Registration
10:45 - 11:00 Opening Remarks
11:00 - 12:15

Scientific Session 1: Vector Biology and Transmission
Chairs: Sebastian Kirschner, Gunnar Mair

11:00 - 11:30

Keynote Lecture
The complexity of Anopheles-Plasmodium interactions (and a novel strategy to block them)

Flaminia Catteruccia - Harvard TH Chan School of Public Health, USA

11:30 - 11:45

Conserved heterodimeric structure & glycan specificity of C-type lectins Anopheles gambiae CTLMA2 and CTL4
Ritika Bishnoi - The Lewis Katz School of Medicine at Temple University, USA

11:45 - 12:00

The regulatory genome of the human malaria vector, Anopheles gambiae: an integrated analysis of chromatin accessibility and transcription
Elena Gómez-Díaz - Spanish National Research Council, Spain

12:00 - 12:15

Glycosylation of Plasmodium falciparum thrombospondin repeats drives mosquito transmission and sporozoite virulence
Justin Boddey - The Walter and Eliza Hall Institute of Medical Research, Australia

12:15 - 13:45 Lunch and Meet the Keynote Speaker
12:45 - 13:45 Workshop: Crowdsourcing Data Science Challenges in Malaria Research
Chairs: Geoffrey Siwo, Carol Sibley
12:45 - 13:45 Workshop: Online Resources for Malaria Biology
Chairs: Matt Berriman, Omar Harb, Dan Lawson
13:45 - 15:30 Scientific Session 2: BIG Data and New Tools
Chairs: Jessica Bryant, Edgar Deu
13:45 - 14:15

Keynote Lecture
The excitement and limitation of a reference genome

Thomas Otto - University of Glasgow, UK

14:15 - 14:30 Using experimental genetic crosses and bulk segregant analysis to investigate Plasmodium falciparum fitness determinants throughout the life cycle
Sudhir Kumar - Seattle Children’s Research Institute, USA
14:30 - 14:45

Comparative mapping of Plasmodium proteomes provides new insights into erythrocyte remodelling
Peter Preiser  - Nanyang Technological University, Singapore

14:45 - 15:00

Decoding a riddle: Plasmodium falciparum long dry season pilgrimage
Richard Thomson Luque - Heidelberg Clinical Hospital, Germany

15:00 - 15:15

IPS cell technology: A great tool to study hypnozoites and pave the road towards malaria elimination
Mélanie Pellisson - Swiss Tropical and Public Health Institute, Switzerland

15:15 - 15:30 Stem cells as a tool to study malaria: the host side of the infection
Alena Pance - The Wellcome Sanger Institute, UK
15:30 - 16:00 Flash Talks - Odd Numbers (abstract: #55, #57, #89, #97, #119, #121, #135, #139)
16:00 - 16:30 Coffee Break and Meet the Keynote Speaker
16:30 - 18:30 Poster Session 1 - Odd Numbers
18:30 - 19:15 Lifetime Achievement Award
19:15 - 20:30 Dinner in the EMBL Canteen
20:30 - 23:00 Welcome Reception in the ATC Rooftop Lounge

Day 2 - Wednesday 29 May 2019
TimeSpeaker
09:00 - 10:30 Scientific Session 3: Development and Differentiation 
Chairs: Bjorn Kafsack, Kathrin Witmer
09:00 - 09:30

Keynote Lecture
Plasmodium gametocyte development: insights from human infection and animal models

Matthias Marti - University of Glasgow, UK

09:30 - 09:45 The patatin-like phospholipase PNPLA1 is crucial for gametocyte induction in the human malaria parasite Plasmodium falciparum
Gabriele Pradel - RWTH Aachen University, Germany
09:45 - 10:00

A parasite load regulator important for virulence and transmission of the malaria parasite Plasmodium falciparum
Alexander G. Maier - The Australian National University Canberra, Australia

10:00 - 10:15

Plasmodium falciparum immature gametocytes development in human primary erythroblasts
Gaëlle Neveu - INSERM, France

10:15 - 10:30

A Histone-Lysine N-Methyltransferase is Required for Efficient Development of Plasmodium in the Mosquito Vector
Sebastian Kirchner - University of Glasgow, UK  

10:30 - 11:00 Coffee Break and Meet the Keynote Speaker
11:00 - 12:30 Scientific Session 4: Drug Development and Resistance
Chairs: Selina Bopp, Stefan Rahlfs
11:00 - 11:30 Keynote Lecture
Targetting Proteostasis for Antimalarial Drug Development

Leann Tilley - The University of Melbourne, Australia
11:30 - 11:45 Cyclic AMP-mediated activation of erythrocyte permeability increases antimalarials uptake by Plasmodium falciparum gametocytes
Catherine Lavazec - INSERM, France   
11:45 - 12:00 Function of Kelch13 in Artemisinin-resistance in malaria parasites
Sabine Schmidt - Bernhard Nocht Institute for Tropical Medicine, Germany   
12:00 - 12:15 Redox homeostasis as a drug target in Plasmodium falciparum gametocytes
Dina Coertzen - University of Pretoria, South Africa 
12:15 - 12:30 A novel antimalarial resistance mechanism leads to structure guided identification of resistance breaking Plasmodium N myristoyltransferase inhibitors
Anja Schlott - The Francis Crick Institute, UK              
12:30 - 14:00 Lunch and Meet the Keynote Speaker
13:00 - 14:00 Workshop: Women In Malaria Research: Visibility, empowerment and leadership
Chairs: Elena Gomez-Diaz, Joanne Power
13:00 - 14:00 Workshop: Drug Discovery for Biologists
Chair: Didier Leroy
14:00 - 15:30 Scientific Session 5: Immunology and Vaccine Development
Chairs: Melanie Walker, Hedda Wardemann
14:00 - 14:30 Keynote Lecture
Immunological impact of subclinical malaria infections

Eleanor Riley - The University of Edinburgh, UK
14:30 - 14:45 Importance of functional antibodies in protection of pregnant women from malaria
Timon Damelang - University of Melbourne, Australia
14:45 - 15:00 Comprehensive analysis of Fc-mediated IgM binding to the Plasmodium falciparum erythrocyte membrane protein 1 family in three parasite clones
Lars Hviid - University of Copenhagen, Denmark
15:00 - 15:15 The discovery of new insertions in antibodies against malaria
Yiwei Chen - Institute for Research in Biomedicine, Switzerland
15:15 - 15:30 B cell profiling in malaria reveals expansion and remodelling of CD11c+ B cell subsets
Christopher Sundling - Karolinska Institutet, Sweden
15:30 - 16:00 Flash Talks - Even Numbers (abstract: #50, #54, #68, #86, #92, #94, #102, #126, #128, #152)
16:00 - 16:30 Coffee Break and Meet the Keynote Speaker
16:30 - 18:30 Poster Session 2 - Even Numbers 
18:30 - 20:30 Conference Dinner in the EMBL Canteen
20:30 - 00:00 Conference Party 

Day 3 - Thursday 30 May 2019
TimeSpeaker
09:00 - 10:30 Scientific Session 6: Cell and Molecular Biology
Chairs: Michael Filarsky, Vera Mitesser
09:00 - 09:30

Keynote Lecture
Plasmodium vivax invasion: structural scaffolds and human monoclonal antibodies
Wai-Hong Tham - The Walter and Eliza Hall Institute of Medical Research, Australia

09:30 - 09:45

Identification of PfAP2-HS as the master regulator of the heat shock response in Plasmodium falciparum parasites
Elisabet Tintó - ISGlobal, Spain

09:45 - 10:00

Formin-2 is the primary nucleator of filamentous actin during intracellular blood stages of P. falciparum, facilitating apicoplast inheritance and completion of cytokinesis
Sujaan Das  - Ludwig Maximillian University, Germany

10:00 - 10:15

Plasmodium falciparum dipeptidyl aminopeptidases 1 and 3 play complementary function in erythrocytes invasion
Edgar Deu - The Francis Crick Institute, UK

10:15 - 10:30

Functional characterization of a minimal ESCRT-III machinery in P. falciparum
Yunuen Avalos Padilla - Institute for Bioengineering of Catalonia, Spain

10:30 - 10:45

Plasmodium condensin (SMC2/SMC4) forms differential complexes and is required for atypical cell division during parasite life cycle
Rita Tewari - University of Nottingham, UK

10:45 - 11:00

Activation of the malarial cGMP dependent protein kinase (PKG) by cGMP: a tale of co-operation and affinity
Konstantinos Kousis  - The Francis Crick Institute, UK

11:00 - 11:30 Coffee Break and Meet the Keynote Speaker
11:30 - 13:00

Scientific Session 7: Host-Parasite Interaction
Chairs: Franziska Hentzschel, Gerhard Wunderlich

11:30 - 12:00 Keynote Lecture
A double-edged sword: innate and adaptive immunity to Plasmodium liver infection

Stefan Kappe - Center for Infectious Disease Research, USA
12:00 - 12:15 Laverania RH5-basigin binding tropisms reveal a key event in the origin of P. falciparum malaria
Francis Galaway - The Wellcome Sanger Institute, UK
12:15 - 12:30

"Microbiota"-A new player in Host-Plasmodium affair
Debanjan Mukherjee - Instituto de Medicina Molecular, Portugal

12:30 - 12:45 var gene expression in malaria naive volunteers experimentally infected with two genetically different P. falciparum strains
Jan Stephan Wichers - Bernhard Nocht Institute for Tropical Medicine, Germany
12:45 - 13:00 Combining reverse genetics and live microscopy to dissect P. knowlesi invasion of red blood cells
Melissa Hart - London School of Hygiene and Tropical Medicine, UK
13:00 - 15:00 Lunch and Meet the Keynote Speaker
13:30 - 15:00 Plenary Session: Changing Practices in Publishing
Chair: Gary Ward
15:00 - 15:10 Awards for Best Poster and Oral Presentations
15:10 - 15:20 Closing remarks
15:20 - 15:30

Departure
Bus to Heidelberg downtown
Bus to Frankfurt Airport