Session 1: Cancer genetics and mutation

Somatic evolution in healthy and diseased bladder urothelium
Inigo Martincorena, Wellcome Trust Sanger Institute, UK

A Pan-Cancer Analysis reveals Nonstop Mutations causing SMAD4 Tumor Suppressor Degradation
Sven Diederichs, University of Freiburg, Germany

Large-scale analysis of liver cancer evolution in five species
Duncan Odom, German Cancer Research Center, Germany

Full-length transcript isoforms associated with SF3B1 mutation in chronic lymphocytic leukemia
Angela Brooks, University of California, Santa Cruz, USA

Coffee break

Understanding epitopes that drive T cell activation in cancer
Matthew L. Meyerson, Dana-Farber Cancer Institute, USA

Comparison of somatic mutational processes across mammalian species
Alex Cagan, Wellcome Sanger Institute, UK

Genotoxic pks+ E. coli induces a unique mutational signature in human colorectal cancer
Axel Rosendahl Huber, Princess Máxima Center, The Netherlands

Oxidative DNA damage repair switches mutagenic outcomes in coding sequence dependent on the epigenome
Anna Poetsch, St. Anna Children's Cancer Research Institute, Austria

Coffee break

Keynote:
Hereditary predisposition to childhood cancer
Stefan M. Pfister, Hopp Children's Cancer Center Heidelberg (KiTZ), Germany

Digital poster presentations and Meet the speakers of Day 1 in the ATC Foyer

Building personalized cancer vaccines
Catherine J. Wu, Dana-Farber Cancer Institute, USA

Single-cell transcriptomics predicts relapse in infants with acute lymphoblastic leukemia
Frank Holstege, Princess Máxima Center for Pediatric Oncology, The Netherlands

Computational study of the mechanisms of response to immunotherapy by transcriptomic analysis of the tumor immune microenvironment in melanoma
Yamil Damian Mahmoud, Instituto de Biología y Medicina Experimental – CONICET, Argentina

Tumor Genomic Profiling to Identify Therapeutic Biomarkers and Guide Clinical Care
Michael F. Berger, Memorial Sloan Kettering Cancer Center, USA

Coffee break

Somatic mutations in normal tissues
Peter Campbell, Wellcome Trust Sanger Institute, UK

Lack of HLA affinity-based neoantigen depletion signals in the cancer genome when considering mutational sequence contexts
Jimmy Van den Eynden, Ghent University, Belgium

Life History of Normal Human Lymphocytes Revealed By Somatic Mutations
Heather Machado, Wellcome Trust Sanger Institute, UK

Lunch

Poster Session 1 (odd numbers)

Session 3: Cancer genome and epigenome

Deciphering the evolutionary paths of tumor progression in Small Cell Lung Cancer
Julie George, University of Cologne, Germany

Epigenetic and transcriptional reprogramming underlies lung adenocarcinoma histological intra-tumor heterogeneity and microenvironment composition
Giovanni Ciriello, University of Lausanne, Switzerland

Reconstructing shattered chromosomes in oesophageal adenocarcinomas
Jannat Ijaz, Wellcome Sanger Institute, UK

Genomic Alterations Across Molecular Subtypes of Mantle Cell Lymphoma
Elías Campo, Hospital Clinic of the University of Barcelona, Spain

Conference Dinner in the EMBL Canteen

The U1 Spliceosomal RNA is Recurrently Mutated in Multiple Cancers
Shimin Shuai, Ontario Institute for Cancer Research, Canada

Functional genomic studies of cancer immune evasion using in vitro and in vivo CRISPR/Cas9 genetic screens
Dimitrios Garyfallos, University of Cambridge, UK

The mutational footprints of cancer therapies
Núria López-Bigas, ICREA, Institute for Research in Biomedicine, Spain

Jan Korbel, EMBL Heidelberg, Germany

Uncovering the role of the disruption of ubiquitin mediated proteolysis in tumorigenesis
Francisco Martinez-Jimenez, IRB, Spain

Elevated pyrimidine dimer formation at distinct genomic bases underlies promoter mutation hotspots in UV-exposed cancers
Kerryn Elliott, University of Gothenburg, Sweden

Session 5: Cancer genome medicine

Mathew Garnett, Wellcome Trust Sanger Institute, UK

Oncologic therapy shapes the fitness landscape of clonal hematopoiesis
Elli Papaemmanuil, Memorial Sloan Kettering Cancer Center, USA

Molecular minimal residual disease detection in AML and clonal hematopoiesis
Peter J.M. Valk, Erasmus University Medical Center, The Netherlands

Bus departures downtown
and to Frankfurt Airport (airport shuttle tickets for sale at registration desk)