Location & dates EMBL Heidelberg, Germany 6 - 8 Feb 2019
Deadlines Registration closed Abstract submission closed

Programme

Got something to say? Tweet it! #EMBLCryoEM

Day 1 - Wednesday 6 February 2019
TimeSpeaker
11:30-13:15

Arrival, registration and light lunch

13:15-13:30 Welcome and Opening Remarks
13:30-15:30 Session 1 - Cryo-EM Overview
Chair: 
Christoph Müller
13:30-14:00

Mechanistic insights from high-resolution cryoEM structures of ATP synthases
Werner Kühlbrandt - Max Planck Institute of Biophysics, Germany

14:00-14:30

Building cryo-EM at Genentech to enable drug discovery
Claudio Ciferri - Genentech, USA

14:30-15:00

Trusting and improving cryoEM information: Doing better and with more image processing quality indicators, while assuring complete process traceability
José María Carazo - CNB-CSIC, Spain

15:00-15:15

Application of Cryo-EM for drug discovery and development at Amgen
Xin Huang – Amgen Inc., USA

15:15-15:30

MicroED: the new tool for the Structural (Bio)Chemist
Sacha De Carlo - Dectris AG, Switzerland

15:30-16:00

Coffee Break and Meet the Speaker with:
Werner Kühlbrandt
Claudio Ciferri
José María Carazo

16:00-18:00

Session 2 - Cryo-EM in Industry Workflows
Chair: Friedrich Rippmann

16:00-16:30

Crystals or grids? Integrating Cryo-EM into the SGC membrane protein pipeline
Katharina Dürr - University of Oxford, UK

16:30-17:00

The architecture of DNA damage repair PIKK kinases and their molecular mechanisms of regulation
Taiana Maia de Oliveira - AstraZeneca, UK

17:00-17:30

Cryo-EM in mid-sized pharma: challenges and achievements @ Merck
Yves Fomekong Nanfack - EMD Serono, USA

17:30-18:00

Cryo-EM: a (new) tool for drug discovery at Novartis
Christian Wiesmann - Novartis, Switzerland

18:00-19:30

Poster session

19:30-21:00

Dinner
EMBL Canteen

21:00-23:00 After Dinner Drinks
ATC Rooftop Lounge
Day 2 - Thursday 7 February 2019
TimeSpeaker
09:00-12:30 Session 3 - Cryo-EM “Success Stories” in Industry and Academia 
Chair: Christian Engel
09:00-09:30

Talk Title: TBC
Priyanka Abeyrathne - GlaxoSmithKline Vaccines, USA

09:30-10:00

The signalling conformation of the human insulin receptor ectodomain
Mike Lawrence - Walter and Eliza Hall Institute of Medical Research, Australia

10:00-10:15

Structure of the human MHC-I peptide-loading complex
Dovile Januliene - Max Planck Institute of Biophysics, Germany

10:15-10:30

Structure and function of the human multidrug transporter ABCG2 
Ioannis Manolaridis – ETH Zurich, Switzerland

10:30-11:00 Coffee Break and Meet the Speakers with:
Katharina Dürr
Taiana Maia de Oliveira
Yves Fomekong Nanfack
Christian Wiesmann
Priyanka Abeyrathne
Mike Lawrence
11:00-11:30

Advantages of an EM approach to therapeutic design
Stephen P. Muench - University of Leeds, UK

11:30-12:00

Active-state GPCR structures by cryo-EM; past, present, future...?
Patrick M. Sexton - Monash University, Australia

12:00-12:15

Cryo-EM structure of the human neutral amino acid transporter ASCT2
Cristina Paulino – University of Groningen, The Netherlands

12:15-12:30

Cryo-EM structure of the lipid transporter MLA
Daniel Mann - University of Sheffield, UK

12:30-14:00

Lunch 
ATC Foyer

14:00-16:00

Session 4 - Sample Optimization for Cryo-EM
Chair: Christian Engel 

14:00-14:30

Detergent-free solubilisation of membrane proteins for biochemical and structural characterisation
Timothy Dafforn - University of Birmingham, UK

14:30-15:00

Saposin lipid nanoparticles for structure determination of membrane proteins
Christian Löw - EMBL Hamburg, Germany

15:00-15:30

Structure determination of GPCRs: cryo-EM compared to X-ray crystallography
Chris Tate - MRC Laboratory of Molecular Biology, UK

15:30-15:45

Pushing the size limit of cryo-EM on small membrane proteins using an entry-level electron microscope
Jiansen Jiang – National Institutes of Health, USA

15:45-16:00

Mechanisms of GABAA receptor signalling revealed by structural pharmacology
Simonas Masiulis – MRC Laboratory of Molecular Biology, UK

16:00-16:30 Coffee Break and Meet the Speakers with:
Stephen P. Muench
Patrick M. Sexton
Timothy Dafforn
Christian Löw
Chris Tate
16:30-19:00

Session 5 – Models of operation
Chair: Chun-wa Chung

16:30-17:00

Cryo-EM: microscopy vs data collection
Wim Hagen - EMBL Heidelberg

17:00-17:30

The Cambridge Pharmaceutical Cryo-EM Consortium
Kasim Sader - Thermo Fisher Scientific, UK

17:30-18:00

Integrative structural biology of HIV-1 and host interactions
Peijun Zhang - Diamond Facility

18:00-19:00

Panel Discussion

19:00-20:30

Dinner in the EMBL Canteen

20:30-23:00

After Dinner Drinks, live Jazz
ATC Rooftop Lounge

Day 3 - Friday 8 February 2019
TimeSpeaker
09:00-12:15

Session 6 - Future Developments in Cryo-EM
Chair: Chun-wa Chung

09:00-09:30

Phase plates in cryo-EM
Radostin Danev - University of Tokyo, Japan

09:30-10:00

Chameleon: A pico-litre dispense, self-wicking system for automated plunge freezing
Paul Thaw- TTP Labtech, UK

10:00-10:15

VitroJet: Next generation sample preparation for cryo-EM
Gulia Weissenberger - CryoSol-World, The Netherlands

10:15-10:30

iNEXT: Infrastructure for NMR, EM and X-rays for translational research
Anastassis Perakis

10:30-11:00 Coffee Break and Meet the Speakers with:
Wim Hagen
Kasim Sader
Peijun Zhang
Radostin Danev
Paul Thaw
John Briggs
Julia Mahamid
11:00-11:30

Cryo-electron tomography to study enveloped virus structure
John Briggs - MRC Laboratory of Molecular Biology, UK

11:30-12:00

Molecular views into cells by in situ cryo-electron tomography
Julia Mahamid - EMBL Heidelberg, Germany

12:00-12:15

Closing remarks and Poster Prizes

12:15-13:30

Lunch followed by Departure

13:00-13:30

EMBL Cryo-EM facility tour 1
Separate Registration required – please await further information before event 

13:30-14:00

EMBL Cryo-EM facility tour 2
Separate Registration required – please await further information before event