Location & dates EMBL Heidelberg, Germany 3 - 8 Nov 2019 Register interest
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Course Overview

In the last decade, several new genetically modified immune deficient mouse strains have been developed. They allowed high levels of engraftment of the human immune system, tissues and tumours. These models have become highly relevant for basic research to understand the function of the human immune system and the development of human pathologies (infections and cancer) in vivo. They are also being increasingly used as potency and safety models to evaluate new therapies and approaches in regenerative medicine prior to testing in humans. 

This course will cover all aspects of the topic, including conceptual and technical classes on human stem cell transplantation and immune reconstitution, infections with human-specific pathogens (EBV, HIV, HCV, HBV, Ebola, Adenovirus), in vivo modelling using patient-derived xenografts (PDX) of solid tumours and leukaemia models as well as regenerative approaches for the liver. 

The Jackson Laboratory will provide additional support for the course, which will take place at the EMBL Advanced Training Centre in Heidelberg, which provides state-of-the-art laboratory space in an exciting academic environment. Besides presenting lectures, the speakers will be involved in wet-lab activities with the PhD students and Post-docs using humanized mice: isolation of cells and tissues, analysis of cell panels by flow cytometry, as well as histological and molecular analyses. Finally, we will discuss the value and impact of these models on the biology and therapy of human diseases.

Audience

Junior faculty, post-docs and pre-docs in the field, who will be selected based on their letter of motivation, curriculum vitae, level of pre-education and training in the fields of immunology, infectious diseases, oncology, pharm-tox. The goal is to promote their intellectual and practical training in the development and analyses of predictive humanised mouse models.

Modules/Resources

  • Mouse strains optimised for humanisation

  • Engraftment of human hematopoietic stem cells, human tissues and human malignancies

  • Human innate and adaptive immune reconstitution in vivo

  • Modelling infections with human pathogens in vivo

  • Modelling human malignancies in vivo

  • Proof-of-concepts for regenerative medicine

  • Regulatory aspects of non-clinical and pharm-tox studies in humanised mice

Learning Outcomes

  • Material and technical requirements for setting up humanized mouse models

  • Dynamics of human immune reconstitution in humanized mice and functional assays

  • Outcome of human infections in humanized mice and testing therapies

  • Outcome of human malignancies in humanized mice and testing therapies

  • Requirements for reproducibility of data for predictive dynamic models

For an impression of the course check the 2017 course programme.

 

EMBL Courses and Conferences are kindly supported by our Corporate Partnership Programme

Founder partners

  • Leica logo
  • Olympus logo

Corporate partners

  • 10x Genomics_120x82
  • Becton Dickinson logo
  • Boehringer Ingelheim logo
  • Eppendorf logo
  • GSK logo
  • Milteniy Biotec_logo120
  • Sartorius
  • ThermoFisher logo

Associate partners

  • Merck logo
  • NEB_logo_120
  • Nikon logo
  • Promega logo
  • Roche logo
  • Sanofi logo