EMBL Courses and Conferences during the Coronavirus pandemic
With the onsite programme paused, many of our events are now being offered in virtual formats.
Registration is open as usual for many events, with back-up plans in place to move further courses and conferences online as necessary. Registration fees for any events affected by the COVID-19 disruption are fully refundable.
More information for participants of events at EMBL Heidelberg can be found here.
In the last decade, several new genetically modified immune deficient mouse strains have been developed. They allowed high levels of engraftment of the human immune system, tissues and tumours. These models have become highly relevant for basic research to understand the function of the human immune system and the development of human pathologies (infections and cancer) in vivo. They are also being increasingly used as potency and safety models to evaluate new therapies and approaches in regenerative medicine prior to testing in humans.
This course will cover all aspects of the topic, including conceptual and technical classes on human stem cell transplantation and immune reconstitution, infections with human-specific pathogens (EBV, HIV, HCV, HBV, Ebola, Adenovirus), in vivo modelling using patient-derived xenografts (PDX) of solid tumours and leukaemia models as well as regenerative approaches for the liver.
The Jackson Laboratory will provide additional support for the course, which will take place at the EMBL Advanced Training Centre in Heidelberg, which provides state-of-the-art laboratory space in an exciting academic environment. Besides presenting lectures, the speakers will be involved in wet-lab activities with the PhD students and Post-docs using humanized mice: isolation of cells and tissues, analysis of cell panels by flow cytometry, as well as histological and molecular analyses. Finally, we will discuss the value and impact of these models on the biology and therapy of human diseases.
Junior faculty, post-docs and pre-docs in the field, who will be selected based on their letter of motivation, level of pre-education and training in the fields of immunology, infectious diseases, oncology, pharm-tox. The goal is to promote their intellectual and practical training in the development and analyses of predictive humanised mouse models.
Mouse strains optimised for humanisation
Engraftment of human hematopoietic stem cells, human tissues and human malignancies
Human innate and adaptive immune reconstitution in vivo
Modelling infections with human pathogens in vivo
Modelling human malignancies in vivo
Proof-of-concepts for regenerative medicine
Regulatory aspects of non-clinical and pharm-tox studies in humanised mice
Material and technical requirements for setting up humanized mouse models
Dynamics of human immune reconstitution in humanized mice and functional assays
Outcome of human infections in humanized mice and testing therapies
Outcome of human malignancies in humanized mice and testing therapies
Requirements for reproducibility of data for predictive dynamic models
For an impression of the course check the 2017 course programme.