Bus departure to EMBL Heidelberg

Arrival and registrations with light lunch

Welcome & introduction
Yvonne Yeboah - EMBL Heidelberg, Germany

Flex Lab A & B

Lecture: Humanized mice: from academia to a global market
Leonard Shultz - The Jackson Laboratory, USA

Flex Lab A & B

5 min flash talks by speakers
Chair: Renata Stripecke - Hannover Medical School, Germany

Flex Lab A & B

5 min flash talks by participants
Chair: Brian Soper - The Jackson Laboratory, USA

Flex Lab A & B

Bus departure to Neckarmünzplatz

EMBL bus stop

Guided tour of Heidelberg and casual dinner (reservation for 19:30)

Urban Kitchen

Bus departure to EMBL Heidelberg

Part 1: Reconstructing the human immune system in vivo
Chair: Renata Stripecke - Hannover Medical School, Germany

Lecture: HSCs and human hematopoiesis in vivo
Dominique Bonnet - The Francis Crick Institute, UK

Flex Lab A & B

Lecture: New strains, immunity and autoimmunity
Michael Brehm - University of Massachusetts Medical School, USA

Flex Lab A & B

Coffee break

Flex Lab A & B

Lecture: T and NK cell development
James Di Santo - Institut Pasteur, France

Flex Lab A & B

Lecture: Human adaptive T and B immunity
Renata Stripecke - Hannover Medical School, Germany

Flex Lab A & B

Lunch break

EMBL Canteen

Lecture: Tools and optimized workflows for the analysis of human cells from humanized mouse models
David Agorklu - Miltenyi Biotech, Germany

Flex Lab A & B

Lecture: Multicolor flow cytometry
Diana Ordonez - EMBL Heidelberg, Germany

Practical: Selection of human hematopoietic stem cells, T cells, monocytes for humanization, harvest tissues from humanized mice and analyses of immune reconstitutions by FACS
Corinna Klein - Heidelberg Institute for Steam Cell technology and Experimental Medicine, Germany
Diana Ordonez - EMBL Heidelberg, Germany
Sebastian Theobald - Hannover Medical School, Germany

Dinner

EMBL Canteen

Poster Session (Odd Numbers)

top of Helix B

Bus departure to Holiday Inn ExpressHeidelberg - City Centre

EMBL bus stop

Bus departure to EMBL Heidelberg

Part 2: Infections with human pathogens
Chair: Christian Muenz - University of Zurich, Switzerland

Lecture: EBV and KSV infections
Christian Muenz - University of Zurich, Switzerland

Flex Lab A & B

Lecture: Adenovirus and Ebola virus infections
Estefania Rodriguez-Burgos - Heinrich Pette Institute Hamburg, Germany

Flex Lab A & B

Coffee break

Flex Lab A & B

Lecture: B cell responses against HIV
Florian Klein - Centre for Molecular Medicine Cologne, Germany

Flex Lab A & B

Lecture: Gene therapy against HIV
Scott Kitchen - University of California Los Angeles, USA

Flex Lab A & B

Lunch break

EMBL Canteen

Lecture: Histopathology
Estefania Rodriguez-Burgos - Heinrich Pette Institute Hamburg, Germany

Flex Lab A & B

Lecture: Quantitative PCR
Kanika Vanshylla - Center for Molecular Medicine Cologne, Germany

Flex Lab A & B

Practical: RNA samples obtained from mice with infections ( HIV, AdV, EBV,HCMV, Ebola) analyzed by real time quantitative PCR for quantification of infections. Pre-fixated tissue sections and cells analyzed for detection of viral antigens by microscopy
Scott Kitchen - University of California Los Angeles, USA
Kanika Vanshylla - Center for Molecular Medicine Cologne, Germany
Estefania Rodriguez-Burgos - Heinrich Pette Institute Hamburg, Germany

Pizza and Poster Session (Even Numbers)

top of Helix B

Bus departure to Holiday Inn ExpressHeidelberg - City Centre

EMBL bus stop

Bus departure to EMBL Heidelberg

Part 3: Patient derived transplants (PDX) for oncology research
Chair: J.J. Schuringa - University of Groningen, The Netherlands

Lecture: Ossicle implants for engraftment of hematopoietic stem cells and leukemia
J.J. Schuringa - University of Groningen, The Netherlands

Flex Lab A & B

Lecture: PDX models combined with human immune system
Brian Soper - The Jackson Laboratory, USA

Flex Lab A & B

Coffee break

Flex Lab A & B

Lecture: Minimal Information for Patient-Derived Tumor Xenograft Models
Terrence Meehan - EMBL-EBI Hinxton, UK

Flex Lab A & B

Lecture: Population-scale studies with PDX for precision medicine for colorectal cancer research
Livio Trusolino - University of Torino Medical School, Italy

Flex Lab A & B

Lunch break

EMBL Canteen

Lecture: In silico genomics analyses
Terrence Meehan - EMBL-EBI Hinxton, UK
J.J. Schuringa - University of Groningen, The Netherlands
Livio Trusolino - University of Torino Medical School, Italy

Flex Lab A & B

Practical: In silico genomics analyses of mutations and tumor heterogeneity analyses, representative examples
Terrence Meehan - EMBL-EBI Hinxton, UK
Ross Thorne - EMBL-EBI Hinxton, UK
J.J. Schuringa - University of Groningen, The Netherlands
Livio Trusolino - University of Torino Medical School, Italy

Dinner

EMBL Canteen

Selected short talks (4x) and round table discussion: challenges in the field

Flex Lab A & B

Bus departure to Holiday Inn ExpressHeidelberg - City Centre

EMBL bus stop

Bus departure to EMBL Heidelberg

Part 4: Immuno-oncology and transplantation
Chair: Brian Soper - The Jackson Laboratory, USA

Lecture: Genetic heterogeneity of AML and pancreatic cancer
Andreas Trumpp - German Cancer Research Center , Germany

Flex Lab A & B

Lecture: Immuno-oncology of breast cancer
Anja Wege - University Medical Center Regensburg, Germany

Flex Lab A & B

Coffee break and Group Photo

Flex Lab A & B

Lecture: Application of PDX for triple negative marker breast cancer research
Carol Bult - The Jackson Laboratory, USA

Flex Lab A & B

Lecture: Humanized mice and organoids in transplantation research
Kourosh Saeb-Parsy - University of Cambridge, UK

Flex Lab A & B

Lunch break

EMBL Canteen

Lecture: Video
Brian Soper - The Jackson Laboratory, USA
Li-Chin Yao - The Jackson Laboratory, USA

Flex Lab A & B

Practical: Humanized mice implanted with patient-derived malignancies
Anja Wege - University Medical Center Regensburg, Germany
Li-Chin Yao - The Jackson Laboratory, USA
Kourosh Saeb-Parsy - University of Cambridge, UK

Bus departure to Holiday Inn ExpressHeidelberg - City Centre

Bus departure to Wirtshaus zum Nepomuk (walk from the Old Bridge)

Dinner Downtown

Wirtshaus zum Nepomuk

Bus departure to EMBL Heidelberg

Part 5: Regenerative medicine and the regulatory perspective
Karl-Dimiter Bissig - Duke University Medical Center, USA

Lecture: Human liver chimeric mouse models – the chances & challenges
Karl-Dimiter Bissig - Duke University Medical Center, USA

Flex Lab A & B

Lecture: Overcoming liver injury through regenerative medicine
Amar Sharma - Hannover Medical School, Germany

Flex Lab A & B

Lecture: Tissue immunophenotyping and cell quantifications
Silvia Guionaud - AstraZeneca, UK

Flex Lab A & B

Coffee break

Flex Lab A & B

Lecture: Humanized mice in drug discovery
Johannes Sam - Roche Zurich, Switzerland

Flex Lab A & B

Lecture: The regulatory perspective of the FDA
Kristina Howard - Food and Drug Administration, USA

Flex Lab A & B

Lunch break

EMBL Canteen

Round table discussion and closing remarks

Flex Lab A & B

Bus departure to Hauptbahnhof, Crowne Plaza, Holiday Inn Express Heidelberg City Centre

EMBL bus stop