Location & dates EMBL Heidelberg, Germany 13 - 16 Nov 2019
Deadlines Registration closed Abstract submission closed
organiser_EMBO_Workshop_2017

Programme

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Day 1 - Wednesday 13 November 2019
TimeSpeaker
12:00 - 13:30 Arrival and Registration
with light lunch
13:30 - 13:45 Opening Remarks
13:45 - 17:15

Session 1: Molecular Basis of Health and Disease
Chair: TBC

13:45 - 14:15

Understand the similarities and differences between normal and malignant stem cells to develop more efficient therapies for AML patients
Caroline Pabst - Heidelberg University Hospital, Germany

14:15 - 14:45 Highthroughput genetics and embryonic development
Emma Farley - University of California, San Diego, USA 
14:45 - 15:00

Understanding genetic and epigenetic T-cell regulatory mechanisms in autoimmune diseases
Neha Daga - EMBL Heidelberg, Germany

15:00 - 15:30

Functional fine-mapping of immune disease variants points towards gene expression modulation in CD4 regulatory T cells
Gosia Trynka - Wellcome Sanger Institute, UK 

15:30 - 16:00

Coffee Break and Meet the Speakers in ATC Foyer

16:00 - 16:30

Spatial proteomics and cell biology
Emma Lundberg - KTH Royal Institute of Technology, Sweden 

16:30 - 16:45

Whole genome sequencing insights into infertility: Preliminary results from WGS of couples with repeated IVF failure
Anna Mantzouratou - Bournemouth University, UK

16:45 - 17:15

Bioinformatics for personalized medicine: Looking beyond the genome
Christoph Bock - CeMM Research Center for Molecular Medicine, Austria

17:15 - 18:00

Keynote Lecture: Precision health: Stem cell based technologies
Hiromitsu Nakauchi - Stanford University, USA 

18:00 - 19:30

Speed Networking Session in ATC Foyer

19:30 - 21:00

Dinner in EMBL Canteen

21:00 - 23:00

Welcome Reception in ATC Rooftop Lounge

Day 2 - Thursday 14 November 2019
TimeSpeaker
09:00 - 12:30 Session 2: Big Data and Genotype to Disease Predictions
Chair: TBC
09:00 - 09:30

Pinpointing disease-causing regulatory genetic variants by multi-omics and machine learning
Julien Gagneur - Technical University of Munich, Germany 

09:30 - 09:45

Characterizing the phenotypic effects of genetic variants associated with transcriptomic outliers in iPSC and differentiated cell-types
Craig Smail - Stanford University, USA

09:45 - 10:00

Data integration for prediction of time to insulin in type 2 diabetes patients
Rikke Linnemann Nielsen - Technical University of Denmark, Denmark

10:00 - 10:30

The power of multi-omics for finding novel disease stratifications
Wolfgang Huber - EMBL Heidelberg, Germany 

10:30 - 11:00

Coffee Break and Meet the Speakers in ATC Foyer

11:00 - 11:30

Population genomics and genetics of complex traits
Emmanouil Dermitzakis - University of Geneva Medical School, Switzerland

11:30 - 11:45

A longitudinal big data approach for precision health
Sophia Miryam Schüssler-Fiorenza Rose - Stanford University, USA

11:45 - 12:00

Multiplexed Cas12a-Cpf1-based screening enables machine learning prediction of an optimal evolving barcoding strategy for targeted therapy drug resistance characterization in cancer
Nicholas Hughes - Stanford University, USA

12:00 - 12:30

Computation approaches to understanding the genotype-phenotype map on a genome-wide scale
Oliver Stegle - EMBL Heidelberg and German Cancer Research Center, Germany

12:30 - 14:00

Lunch and Meet the Editors in ATC Foyer

14:00 - 16:45

Session 3: Clinical, Ethical and Societal Issues
Chair: TBC

14:00 - 14:30

Novel application of sequencing technologies to non-invasive diagnostics, immune repertoire analysis, and de novo genome sequencing
Stephen Quake - Stanford University, USA 

14:30 - 14:45

Microbiome in active and in active older people
Nathan O'Callaghan - CSIRO, Australia

14:45 - 15:15 Pioneering new approaches in predictive, preventative, personalized, and participatory healthcare
Leroy Hood - Institute for Systems Biology, USA
15:15 - 15:45

The value(s) of Precision Health: Patients and society
Barbara Prainsack - King's College London, UK and University of Vienna, Austria 

15:45 - 16:15

Coffee Break and Meet the Speakers in ATC Foyer

16:15 - 16:45

Big data in health and biology 
Ewan Birney - EMBL-EBI Hinxton, UK

16:45 - 17:30

Keynote Lecture: Genetic and epigenetic variation and their impact on chromosome conformation and gene expression differences in development and disease. Using X inactivation and autosomal monoallelic gene expression as model systems
Edith Heard - EMBL Heidelberg, Germany

17:30 - 18:00

Flash Talks Session

18:00 - 19:30

Poster Session 1 (odd numbers)
with beer, wine and snacks

19:30 - 21:00 Dinner in EMBL Canteen
Day 3 - Friday 15 November 2019
TimeSpeaker
09:00 - 17:00 Session 4: Precision Medicine in Practice
Chair: TBC
09:00 - 09:30

Longitudinal sampling of menstrual fluid for applications in early detection and monitoring of gynaecological malignancy
Angela Goncalves - German Cancer Research Center, Germany

09:30 - 09:45

Identification of a reproducible epigenetic risk profile for schizophrenia linked to post-mortem brain methylation and prefrontal-hippocampal connectivity
Emanuel Schwarz - Central Institute of Mental Health, Germany

09:45 - 10:00

The use of iPSCs for in vivo personalized organ generation using cross-species chimeras: A primate model
Morteza Roodgar - Stanford University, USA

10:00 - 10:30

Harnessing big data for personalized medicine
Eran Segal - Weizmann Institute of Science, Israel 

10:30 - 11:00

Coffee Break and Meet the Speakers in ATC Foyer

11:00 - 11:30

Personalizing ICU meditine: How genomics is advancing our understanding of ARDS
Angela Rogers - Stanford University, USA

11:30 - 11:45

Selected short talk

11:45 - 12:00

Navigating causal-reasoning pathways to identify personalize drug-treatments through multi-omics using multi-task learning
Rosa Hernansaiz Ballesteros - Heidelberg University, Germany

12:00 - 12:30

Ex vivo drug efficacy testing on patient-derived cells combined with omics profiling to personalize treatment
Olli Kallioniemi - Karolinska Institutet, Sweden 

12:30 - 14:00

Lunch in ATC Foyer

14:00 - 14:30

Unlocking the secret genes and genomes from the human microbiome
Ami Bhatt - Stanford University, USA 

14:30 - 14:45

DNA methylation relates to cardiac alternative splicing in dilated cardiomyopathy
Weng-Tein Gi - Heidelberg University, Germany

14:45 - 15:00

Quantitative measurement of full-length transcript isoforms reveals precise regulation of splicing in human heart cells
Chenchen Zhu - Stanford University, USA

15:00 - 15:30

Patient centered data in real world medicine
Christof von Kalle - Charité - Berlin Institute of Health, Germany and Sidra Medicine, Qatar

15:30 - 16:00 Coffee Break and Meet the Speakers in ATC Foyer
16:00 - 16:30 The modular proteome and its clinical significance
Ruedi Aebersold - ETH Zurich, Switzerland 
16:30 - 17:00 Development and application of approaches to improve diagnosis, treatment and early detection of cancer
Christina Curtis - Stanford University, USA
17:00 - 17:45 Industry Panel Discussion: Commercialising Precision Health
Moderator: Michael Snyder - Stanford University, USA
Panel members:
Gitte Neubauer - Cellzome, Germany
Eran Segal - Weizmann Institute of Science, Israel 
Christian Fegeler - MOLIT Institute, Germany
17:45 - 19:30

Poster Session 2 (even numbers)
with beer, wine and snacks

19:30 - 21:00

Conference Dinner in EMBL Canteen

21:00 - 00:00

Conference Party with Live Band in ATC Foyer

Day 4 - Saturday 16 November 2019
TimeSpeaker
09:30 - 11:30 Session 5: Wearables and Technology
Chair: TBC
09:30 - 10:00

Theranostic designer cell implant design to correct prominent metabolic disorders
Martin Fussenegger - ETH Zurich, Switzerland 

10:00 - 10:15

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight
Tejaswini Mishra - Stanford University, USA

10:15 - 10:30

Development of a urine-based diagnostic test for selecting a subpopulation of asthmatics
Hoda Sharifian - AstraZeneca, Sweden

10:30 - 11:00

Development of microfluidic technology to address complex questions in biomedical sciences and developmental biology
Christoph Merten - EMBL Heidelberg, Germany

11:00 - 11:30

Ultrasensitive Protein Measurements for Early Disease Detection
David Walt - Wyss Institute at Harvard University, USA 

11:30 - 13:00

Lunch in EMBL Canteen

13:00 - 14:45

Session 6: Disease Models
Chair: TBC

13:00 - 13:30

The failure uncovers heart's wonderful principles
Benjamin Meder - Heidelberg University Hospital, Germany 

13:30 - 13:45

Pathological mutations in LSD1 interfere with ZEB1/2 transcription factor and alter developmental gene expression
Daria Bunina - EMBL Heidelberg, Germany

13:45 - 14:15

Extending the small molecule similarity principle to all levels of biology
Patrick Aloy - Institute for Research in Biomedicine, Spain 

14:15 - 14:45

Extracellular electrophysiological characterization of neurons and networks at subcellular resolution
Andreas Hierlemann - ETH Zurich, Switzerland

14:45 - 15:00 Closing Remarks and Poster Prizes