Location & dates EMBL Heidelberg, Germany 22 - 25 Sep 2019
Deadlines Registration closed Abstract submission closed
organiser_EMBO_Workshop_2017

Pre-Conference Workshop

The following optional pre-conference workshop will be hosted by the conference sponsor GenScript Biotech and will take place before the EMBO Workshop: Creating is Understanding: Synthetic Biology Masters Complexity

Rapid assembly of gene variant libraries and multi-gene pathways with semiconductor technologies

Date: Sunday, 22 September 2019, from 17:30 to 18:30
Venue: EMBL Advanced Training Centre, Courtyard Room A

Presenter: Kimberly M. Arnold, Product Manager, GenScript USA, Inc

 

Engineering synthetic biological systems requires the design, build and testing of multi-gene networks. To optimize a synthetic system with the best combination of DNA parts, synthetic biologists need to test all possible variations of individual components and be able to screen in a combinatorial design space.  But such combinatorial engineering approaches are hindered by the difficulty of simultaneously assembling numerous large, multi-gene constructs from a collection of DNA parts.


Here, we introduce our newly developed variant library synthesis platforms, which creates well-designed mutant libraries containing all desired variants with unbiased distribution. Additionally, our combinatorial library synthesis platform enables in-parallel construction of thousands of multiplexed gene variants in an efficient and economical way. Both platforms utilize our patented semiconductor-based oligonucleotide microarray fabrication technology allowing complete control over codon usage and amino acid distribution. Libraries generated using this method are highly customizable and capable of generating over 1x108 variants. As a result, our platform enables faster, easier, and more cost-effective engineering of metabolic pathways and microbial strains in comparison to alternative approaches.

All conference participants will receive an email with a registration link. 

Participation in the workshop is first come - first served.