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Small molecules play an important role in biological research and drug discovery. Demonstrating target engagement by a small molecule is essential to understand its mechanism of action. This course will give a solid practical and theoretical grounding in evaluating how a small molecule interacts with its biological target in cells or in vitro and its role in drug discovery.
This course is aimed at pre and post doctoral and established researchers developing/using small molecules in drug discovery or for the elucidation of biological questions.
- Cellular Thermal Shift Assay (CETSA)
- Bioluminescence Resonance Energy Transfer (BRET)
- PROTAC: targeted protein degradation
- Computational methods for target identification