Location & dates EMBL Heidelberg, Germany 11 - 15 Mar 2019
Deadlines Application closed
organiser_gsk

Programme

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Day 1 - Monday 11 March 2019
TimeSpeakerLocation
08:30 - 09:00

Arrival & Welcome, Introduction & Overview course and experiments

Joe Lewis, EMBL Heidelberg, Germany 

Flex Lab A & B

09:00 - 09:45

Lecture: Target Identification and Target Engagement: Applications in Drug Discovery

Friedrich Reinhard, Cellzome/ GSK, Germany

Flex Lab A & B

09:45 - 10:00

Coffee break

Foyer

10:00 - 10:45

Practical: CETSA 

Friedrich Reinhard, Cellzome/ GSK, Germany

Training Lab B

10:45 - 12:30

CETSA TR

12:30 - 13:30

Lunch Break

EMBL Canteen

13:30 - 15:45

CETSA ITDR including analysis of Temp

Computer Training Lab

16:00 - 17:00

Lecture: Thermal Proteome Profiling to address questions in fundamental biology and drug discovery

Mikhail Savitski, EMBL Heidelberg, Germany

17:00 - 17:30

Coffee Break

Foyer
17:30 - 18:00

CETSA - Wrap up, CETSA on cells

Training Lab B

18:00 - 19:00

Practical: Chemoproteomics

Friedrich Reinhard, Cellzome/ GSK, Germany

Training Lab B

19:00 - 20:00

Dinner

EMBL Canteen

20:00 - 21:30

Group activity: Flash talks

Flex Lab A & B

Day 2 - Tuesday 12 March 2019
TimeSpeakerLocation
08:45 - 10:00

Practicals in Groups

a) Imaging

b) Chemoproteomics

Training Lab B

10:00 - 11:00

Lecture: Click-probe based approach for target engagement and residence time measurement at single cell level

Anna Rutkowska, GSK, Germany

Flex Lab A & B

11:00 - 13:00

Practicals in Groups continued

Training Lab B

13:00 - 14:00

Lunch break

EMBL Canteen

14:00 - 18:00

Practical in Groups continued

In between: Coffee break

Training Lab B

18:00 - 19:00

Lecture: Genetic methods for target validation

Stefan Kubicek, CeMM, Austria

Flex Lab A & B

19:00 - 20:00

Dinner

EMBL Canteen

Day 3 - Wednesday 13 March 2019
TimeSpeakerLocation
09:00 - 12:00

Practical: Chemoproteomics & start gel for western blot

Training Lab B

Western blot and analysis

Training Lab B

11:00 - 12:00

Lecture: Bioactivity databases and computational modelling in target identification and engagement studies

Andrew Leach, EMBL-EBI, UK

Flex Lab A & B

12:00 - 13:00

Lunch break

EMBL Canteen

13:00 - 14:00

Lecture: NanoBRET TE

Matthew Robers, Promega, USA

Flex Lab A & B

14:00 - 14:15

Coffee Break

Foyer
14:00 - 17:00

NanoBRET TE

during 2 hours incubation: Imaging: Data Analysis and summary

during 2 hours incubation: any chemoproteomics topics left

Training Lab
17:00

Free Evening

Day 4 - Thursday 14 March 2019
TimeSpeakerLocation
08:30 - 11:00

NanoBRET Measurement and data analysis

Computer Training Lab

11:00 - 12:00

Lecture: The implementation of target engagement and residence time NanoBRET assays in compound characterizations and probe development: The SGC experience

Benedict-Tilman Berger, Goethe University Frankfurt, Germany

Flex Lab A & B

12:00 - 13:00

Lunch break

EMBL Canteen

13:00 - 14:00

Lecture: Proteolysis Targeting Chimeras (PROTACs): an ever evolving tool in chemical biology and drug discovery

William Farnaby, The University of Dundee, UK

Flex Lab A & B

14:00 - 14:15

Coffee Break

Foyer

14:15 - 17:00

Practical: PROTAC treatment of cells

Training Lab

17:30

Dinner

Restaurant, downtown Heidelberg

Day 5 - Friday 15 March 2019
TimeSpeakerLocation
09:00 - 10:00

Practical: Protac Measurement and data analysis

Computer Training Lab

10:00 - 11:00

Q&A

Computer Training Lab

11:00 - 12:00

Wrap up and closing

Computer Training Lab
12:00 - 13:00

Lunch break 

EMBL Canteen

13:00

Bus to Heidelberg Train Station and Crown Plaza Hotel