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EMBL Courses and Conferences during the Coronavirus pandemic
With the onsite programme paused, many of our events are now being offered in virtual formats.
Registration is open as usual for many events, with back-up plans in place to move further courses and conferences online as necessary. Registration fees for any events affected by the COVID-19 disruption are fully refundable.
More information for participants of events at EMBL Heidelberg can be found here.
Programme
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Time | Speaker | |
---|---|---|
11:00-13:00 | Arrival and Registration with light refreshments |
|
11:45-12:45 |
Pre-conference workshop | |
13:00-13:30 | Opening talk The challenge of expanding the druggable proteome Adrian Carter, Boehringer Ingelheim, Germany |
|
13:30-15:00 |
Session 1: Illuminating the challenge and highlighting the opportunity for creating new medicines |
|
13:30-14:00 |
Illuminating the Druggable Genome with Informatics, Data Science and Machine Learning |
|
14:00-14:30 |
Functionalization of the human protein-coding genome to discover medicines for neurodegenerative disease |
|
14:30-15:00 |
Chemical probes and the chemical biology of cancer |
|
15:00-15:30 |
Coffee break |
|
15:30-17:45 |
Session 2: Illuminating the most promising proteins by virtue of druggability, human genetics and bioinformatics |
|
15:30-16:00 |
Computational identification of drug targets in cancer |
|
16:00-16:15 |
Proteome-wide identification of new druggable targets for antibiotics |
|
16:15-16:45 |
Target Tractability: Making full use of protein homology |
|
16:45-17:15 |
Epigenetic variation across individuals to understand disease mechanisms |
|
17:15-17:45 |
Extending the small molecule similarity principle to all levels of biology |
|
17:45-18:35 |
Poster Session 1 (odd numbers) |
|
18:35-19:30 |
Poster Session 2 (even numbers) |
|
19:30-20:45 |
Dinner |
|
20:45-22:00 | After Dinner Drinks ATC Rooftop Lounge |
|
20:00, 21:00, 22:00 | Bus departure |
Time | Speaker | |
---|---|---|
09:00-12:30 |
Session 3: Interrogating the druggable proteome with chemical probes, imaging and sensor proteins, part 1 |
|
09:00-09:30 |
Shaping biology by modulating access to chemical matter |
|
09:30-09:45 |
The target landscape of 1,200 kinase inhibitors |
|
09:45-10:00 |
Covalent inhibitors for 'undruggable' targets |
|
10:00-10:30 |
Targeting protein scaffolding function in kinases |
|
10:30-11:00 |
Coffee break |
|
11:00-11:30 |
Exploring the druggable proteome by image-based phenotyping in cell lines and patient derived organoids |
|
11:30-12:00 |
Mechanisms of intracellular DNA sensing through the cGAS-STING pathway |
|
12:00-12:15 |
Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN |
|
12:15-12:30 |
Stabilization of protein-protein interactions |
|
12:30-14:00 |
Lunch and meet the speakers |
|
14:00-16:00 |
Session 4: Interrogating the druggable proteome with chemical probes, imaging and sensor proteins, part 2 |
|
14:00-14:30 |
Tetrahydrobiopterin homeostasis |
|
14:30-15:00 |
Chemical physiology of natural products and antibody conjugates |
|
15:00-15:30 |
Within our control? Leveraging precision electrophile signaling toward drug discovery |
|
15:30-16:00 |
Understanding cellular phenotypes; from screens to probes towards clinical candidates |
|
16:00-16:30 |
Coffee break |
|
16:30-19:00 | Session 5: Interrogating the druggable proteome with phenotypic screens Chair: Herbert Waldmann |
|
16:30-16:45 | Towards improved biophysical models of protein folding to identify disease-causing mutations and rescue by small molecules Amelie Stein - University of Copenhagen, Denmark |
|
16:45-17:00 | Using metabolic fingerprints to rationally design combination therapies Mattia Zampieri - ETH Zürich, Switzerland |
|
17:00-17:30 | Pseudo Natural Products Herbert Waldmann - Max Planck Institute of Molecular Physiology, Germany |
|
17:30-18:00 |
A systems approach to functional precision medicine by deep learning and multi-OMICs |
|
18:00-18:30 | Advances in phenotypic and pathway profiling: Elucidating novel target biology and drug mechanism-of-action under appropriate biological context Neil Carragher - The University of Edinburgh, UK |
|
18:45-20:30 | Conference Dinner EMBL Canteen |
|
20:30-23:00 | After Dinner Drinks, live music ATC Rooftop Lounge |
|
20:00, 21:30, 23:00 | Bus departure |
Time | Speaker |
---|---|
09:00-10:45 | Session 6: New engineering approaches for expanding the druggable proteome Chair: Stefan Knapp |
09:00-09:30 |
Mapping genetic networks using functional and chemical genomics |
09:30-10:00 |
Biophysical screening of combinatorial libraries to target protein-protein interactions with covalent agents |
10:00-10:15 |
NanoBRET cellular target engagement assays are versatile in enabling drug screening for various proteins – the SGC experience |
10:15-10:45 |
Chemical biology at the interface of discovery to deliver novel to targets to the Drug Discovery Pipeline |
10:45-11:15 |
Coffee break |
11:15-13:15 |
Session 7: New engineering approaches for breaking the druggability barrier |
11:15-11:45 |
Targeting the active site of E3 ligases with chemical tools |
11:45-12:15 |
Structure based PROTAC design to expand the druggable proteome |
12:15-12:45 |
Chemical probes in target discovery |
12:45-13:15 |
Identification of microbiome-encoded enzymes involved in drug metabolism |
13:15-13:30 | Closing remarks and Poster Prize |
13:30-14:00 |
End of conference |
14:00 |
Bus departure all stops downtown |
14:10 |
Bus to Frankfurt Intl. Airport |