Location & dates EMBL Heidelberg, Germany 22 - 24 Apr 2020
Deadlines Registration closed Abstract submission closed
organiser_EMBO_Workshop_2017

EMBL Courses and Conferences during the Coronavirus pandemic

With the onsite programme paused, many of our events are now being offered in virtual formats.


Registration is open as usual for many events, with back-up plans in place to move further courses and conferences online as necessary. Registration fees for any events affected by the COVID-19 disruption are fully refundable.


More information for participants of events at EMBL Heidelberg can be found here.

Programme

Got something to say? Tweet it! #EMBOEpitrans

Day 1 - Wednesday 22 April 2020
TimeSpeaker
08:00-09:30 Registration
  Session 1: RNA modification I (m6A)
Chair: TBA
09:30-09:45 Opening remarks
09:45-10:45

Keynote Lecture:

RNA methylation in gene expression regulation
Chuan He - The University of Chicago, USA

10:45-11:15

Reading and writing epitranscriptomic modifications at mRNA caps and at internal sites
Samie Jaffrey - Weill Medical College, Cornell University, USA

11:15-11:30

Mettl3/Mettl14 inhibitors and YTHDF antagonists: when and why to go biophysical with your target

Gerhard Müller - Gotham Therapeutics GmbH, Germany

11:30-12:00

Gene regulation by RNA modifications

Ramesh Pillai - University of Geneva, Switzerland

12:00-13:30

Meet the speakers and Lunch

13:30-13:45

The role of YTHDF readers in maternal transcript clearance and embryonic development

Cassandra Kontur - Yale University, USA

13:45-14:00

NOseq today: fractional occupancy of m6A sites

Mark Helm - Johannes Gutenberg-University, Germany

14:00-14:15

Nanopore direct RNA sequencing identifies interactions between RNA methylation and poly(A) site choice

Matthew Parker - The University of Dundee, UK

14:15-14:30

m6ACE-seq as a tool to identify and characterize RNA methylation writers and erasers

Sho Goh - Genome Institute of Singapore, Singapore

14:30-14:45

METTL3-mediated m6A modifications control antibody immune responses

Amalie Grenov - The Weizmann Institute of Science, Israel

14:45-15:15

Coffee Break

Session 2: RNA modifications in stem cells and development
Chair: TBA

15:15-15:45

Role of RNA methylation in gene regulation and cancer
Richard Gregory - Boston Children's Hospital, USA

15:45-16:15

RNA pseudouridylation in development and tumorigenesis

Cristian Bellodi - Lund University, Sweden

16:15-16:30

Ythdf readers compensate each other in a context specific manner

Noa Novershtern - The Weizmann Institute of Science, Israel

16:30-17:00

Tell-Tale Poly(A) Tails 
Amy Pasquinelli - University of California, San Diego, USA

17:00-19:00

Poster Session I with beer and snacks

19:00-21:00

Dinner

21:00-23:00 Welcome reception with live jazz duo
Day 2 - Thursday 23 April 2020
TimeSpeaker
  Session 2 (cont.) - RNA modifications in stem cells and development
Chair: TBA
09:00-09:30

Cross-evolutionary analysis of RNA acetylation from single nucleotide to near-atomic resolution
Schragi Schwartz - Weizmann Institute of Science, Israel

09:30-09:45

Control of cellular proliferation in plant organogenesis by an m6A-YTHDF module

Laura  Arribas-Hernández - University of Copenhagen, Denmark

Session 3: RNA modification II (m5C, m1A, 3’ terminal additions, etc)
Chair: TBA

09:45-10:15

Effects of RNA modifications on RNA structure
Janus Bujnicki - International Institute of Molecular and Cell Biology, Poland

10:15-10:30

No evidence for N7-methylation of guanosine (m7G) in human miRNAs

Vinther Jeppe - University of Copenhagen, Denmark

10:30-11:00 Coffee break
11:00-11:30

Structure and Function of RNA m6A methyltransferases
Yunsun Nam - The University of Texas Southwestern Medical Center, USA

11:30-11:45

m5C Modification of an Epstein-Barr Virus Noncoding RNA Decreases its Stability

Nara Lee - University of Pittsburgh, USA

11:45-12:00

Molecular Characterization of Uridylation-mediated RNA Decay by the Drosophila TRUMP Complex

Annamaria Sgromo - Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Austria

12:00-13:30

Meet the Speakers and Lunch

13:30-14:00

Acetylation of cytidine in messenger RNA regulates translation

Shalini Oberdoerffer - National Cancer Institute, USA

14:00-14:15

Molecular connection between the TUTase URT1 and decapping activators

Dominique Gagliardi - IBMP-CNRS-University of Strasbourg, France

14:15-14:45

The molecular mechanisms and interactome of human adenosine demethylases
Štěpánka Vaňáčová- CEITEC, Czech Republic

14:45-15:00

Noncanonical poly(A) polymerase TENT5C regulates B cell humoral response and differentiation

Seweryn Mroczek - Warsaw University, Poland

15:00-15:30 Coffee break
Session 4 - RNA modification pathways in physiology and pathology
Chair: TBA
15:30-16:00 Targeting RNA modifications to eliminate cancer stem cells in acute myeloid leukaemia
Kamil Kranc - Barts Cancer Institute, Queen Mary University of London, UK
16:00-16:15

Targeting cancer with first-in-class inhibitors of the RNA m6A writer METTL3

Alexandra Sapetschnig - Storm Therapeutics, UK

16:15-16:45

Modifications of RNA: Their function and role in cancer
Tony Kouzarides - The Gurdon Institute, University of Cambridge, UK

16:45-17:00

The ribosomal RNA m5C methyltransferase NSUN-1 modulates healthspan and fecundity in Caenorhabditis elegans

Markus Schosserer - University of Natural Resources and Life Sciences, Austria

17:00-19:00

Poster Session II

19:00-21:00

Dinner in the EMBL Canteen

21:00-24:00 Party in the Roof Top Lounge
Day 3 - Friday 24 April 2020
TimeSpeaker
  Session 4 (cont.) - RNA modification pathways in physiology and pathology
Chair: TBA
09:00-09:30 mRNA cap regulation in cell fate decisions
Victoria Cowling - University of Dundee, UK
09:30-09:45

Escaping the plant cell: m5C RNA methylation and tRNA-like structures as signals for long-distance mRNA mobility in Arabidopsis

Eleftheria Saplaoura - Max Planck Institute of Molecular Plant Physiology, Germany

09:45-10:00

The ribosomal RNA modification code at single nucleotide resolution

Eva Maria Novoa - Centre for Genomic Regulation, Spain

Session 5 - Emerging concepts
Chair: TBA
10:00-10:30

tRNA m5C in cancer biology
Michaela Frye - German Cancer Research Center, Germany

10:30-10:45

Dinucleoside polyphosphates act as 5' RNA caps in bacteria

Hana Cahova - Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic

10:45-11:15

Coffee break

11:15-11:45

Regulating mammalian gene expression by RNA pseudouridylation
Wendy Gilbert - Yale University, USA

11:45-12:00

Thiolation: not only a tRNA business

Riccardo Pecori - German Cancer Research Center, Germany

12:00-12:30

Making RNA demethylation visible with NAIL-MS
Stefanie Kellner - Ludwig-Maximilians-Universität München, Germany

12:30-12:45

Terminal nucleoitde additions and mRNA decay
Narry Kim - Seoul National University, Korea

12:45-13:15

Closing Remarks

13:15-13:30

Packed Lunch

Bus downtown and Frankfurt Airport (airport shuttle tickets for sale at registration desk)