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There is an increasing awareness that mechanistic structural information on molecular machines is ideally generated within the context of intact cells in order to fully grasp how they function in a complex native environment. Recent technological advances have nurtured the development of such in situ structural biology approaches in several disciplines, including cryo-EM, mass spectrometry, super-resolution microscopy, NMR, computational modelling and others.
This conference will bring together experts and early stage researchers from the separate fields
- to provide a platform for structural biology within the cellular context
- to stimulate discussions about how to meaningfully integrate data from different methods
- to define what types of biological questions can already be addressed using in situ structural biology and which might be approached in the future
- Imaging across scales
- Structural analysis in situ
- Molecular sociology
- Biophysical analysis in cells
- Integrative modelling