Location & dates EMBL Heidelberg, Germany 30 Mar - 3 Apr 2020 Register Now
Deadlines Application - 6 Jan 2020

Course Overview

Small molecules play an important role in biological research and drug discovery. Demonstrating target engagement by a small molecule is essential to understand its mechanism of action. This course will give a solid practical and theoretical grounding in evaluating how a small molecule interacts with its biological target in cells or in vitro, and its role in drug discovery. This course will use proteins of the kinase family to exemplify the general principles and methodologies and their application.


This course is aimed at pre and post doctoral and established researchers developing/using small molecules in drug discovery or for the elucidation of biological questions.


  • Cellular Thermal Shift Assay (CETSA)

  • Chemoproteomics
  • PROTAC (targeted protein degradation) mode of action cascade (nanoBRET and luminescence assays)
  • Photoaffinity Labeling (PAL)
  • Overview on click-probe based approach for target engagement by imaging
  • Overview on computational methods for target identification
  • Overview on genetic methods for target identification (CRISPR-based)


EMBL Courses and Conferences are kindly supported by our Corporate Partnership Programme

Founder partners

  • Leica logo
  • Olympus logo

Corporate partners

  • 10x Genomics_120x82
  • Becton Dickinson logo
  • Bio-Rad
  • Boehringer Ingelheim logo
  • Eppendorf logo
  • GSK logo
  • Milteniy Biotec_logo120
  • Sartorius
  • ThermoFisher logo

Associate partners

  • Merck logo
  • NEB_logo_120
  • Nikon logo
  • Promega logo
  • Roche logo
  • Sanofi logo